TY - JOUR
T1 - IDO expression by dendritic cells
T2 - Tolerance and tryptophan catabolism
AU - Mellor, Andrew L.
AU - Munn, David H.
N1 - Funding Information:
We acknowledge the National Institutes of Health for supporting the research described in this review.
PY - 2004/10
Y1 - 2004/10
N2 - Indoleamine 2,3-dioxygenase (IDO) is an enzyme that degrades the essential amino acid tryptophan. The concept that cells expressing IDO can suppress T-cell responses and promote tolerance is a relatively new paradigm in immunology. Considerable evidence now supports this hypothesis, including studies of mammalian pregnancy, tumour resistance, chronic infections and autoimmune diseases. In this review, we summarize key recent developments and propose a unifying model for the role of IDO in tolerance induction.
AB - Indoleamine 2,3-dioxygenase (IDO) is an enzyme that degrades the essential amino acid tryptophan. The concept that cells expressing IDO can suppress T-cell responses and promote tolerance is a relatively new paradigm in immunology. Considerable evidence now supports this hypothesis, including studies of mammalian pregnancy, tumour resistance, chronic infections and autoimmune diseases. In this review, we summarize key recent developments and propose a unifying model for the role of IDO in tolerance induction.
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U2 - 10.1038/nri1457
DO - 10.1038/nri1457
M3 - Review article
C2 - 15459668
AN - SCOPUS:5044220930
SN - 1474-1733
VL - 4
SP - 762
EP - 774
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 10
ER -