Immunomodulatory properties of carbon nanotubes are able to compensate immune function dysregulation caused by microgravity conditions

Claudia Crescio; Marco Orecchioni; Cécilia Ménard-Moyon; Francesco Sgarrella; Proto Pippia; Roberto Manetti; Alberto Bianco; Lucia Gemma Delogu

doi:10.1039/c4nr02711f

Immunomodulatory properties of carbon nanotubes are able to compensate immune function dysregulation caused by microgravity conditions

Claudia Crescio, Marco Orecchioni, Cécilia Ménard-Moyon, Francesco Sgarrella, Proto Pippia, Roberto Manetti, Alberto Bianco, Lucia Gemma Delogu

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Spaceflights lead to dysregulation of the immune cell functionality affecting the expression of activation markers and cytokine production. Short oxidized multi-walled carbon nanotubes functionalized by 1,3-dipolar cycloaddition have been reported to activate immune cells. In this Communication we have performed surface marker assays and multiplex ELISA on primary monocytes and T cells under microgravity. We have discovered that carbon nanotubes, through their immunostimulatory properties, are able to fight spaceflight immune system dysregulations.

Original language	English (US)
Pages (from-to)	9599-9603
Number of pages	5
Journal	Nanoscale
Volume	6
Issue number	16
DOIs	https://doi.org/10.1039/c4nr02711f
State	Published - Aug 21 2014

ASJC Scopus subject areas

General Materials Science

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abstract = "Spaceflights lead to dysregulation of the immune cell functionality affecting the expression of activation markers and cytokine production. Short oxidized multi-walled carbon nanotubes functionalized by 1,3-dipolar cycloaddition have been reported to activate immune cells. In this Communication we have performed surface marker assays and multiplex ELISA on primary monocytes and T cells under microgravity. We have discovered that carbon nanotubes, through their immunostimulatory properties, are able to fight spaceflight immune system dysregulations.",

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AU - Crescio, Claudia

AU - Orecchioni, Marco

AU - Ménard-Moyon, Cécilia

AU - Sgarrella, Francesco

AU - Pippia, Proto

AU - Manetti, Roberto

AU - Bianco, Alberto

AU - Delogu, Lucia Gemma

PY - 2014/8/21

Y1 - 2014/8/21

N2 - Spaceflights lead to dysregulation of the immune cell functionality affecting the expression of activation markers and cytokine production. Short oxidized multi-walled carbon nanotubes functionalized by 1,3-dipolar cycloaddition have been reported to activate immune cells. In this Communication we have performed surface marker assays and multiplex ELISA on primary monocytes and T cells under microgravity. We have discovered that carbon nanotubes, through their immunostimulatory properties, are able to fight spaceflight immune system dysregulations.

AB - Spaceflights lead to dysregulation of the immune cell functionality affecting the expression of activation markers and cytokine production. Short oxidized multi-walled carbon nanotubes functionalized by 1,3-dipolar cycloaddition have been reported to activate immune cells. In this Communication we have performed surface marker assays and multiplex ELISA on primary monocytes and T cells under microgravity. We have discovered that carbon nanotubes, through their immunostimulatory properties, are able to fight spaceflight immune system dysregulations.

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Immunomodulatory properties of carbon nanotubes are able to compensate immune function dysregulation caused by microgravity conditions

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