Immunoreactive interleukin-1β localization in the rat forebrain

Ronald M. Lechan; R. Toni; B. D. Clark; J. G. Cannon; A. R. Shaw; C. A. Dinarello; S. Reichlin

doi:10.1016/0006-8993(90)90445-H

Immunoreactive interleukin-1β localization in the rat forebrain

Ronald M. Lechan, R. Toni, B. D. Clark, J. G. Cannon, A. R. Shaw, C. A. Dinarello, S. Reichlin

Medical Laboratory, Imaging and Radiologic Sciences

Research output: Contribution to journal › Article › peer-review

336 Scopus citations

Abstract

To determine whether the cytokine, interleukin-1β, is present in the rat brain as has been reported in human brain, immunocytochemical studies were performed using an antiserum that recognizes recombinant, rat IL-1β. Immunoreaction product was present in the periventricular and medial hypothalamus, mossy fiber distribution in the hippocampus and olfactory tubercle. These studies demonstrate that IL-1β is part of a diffuse intrinsic neural system in the rat central nervous system, associated with regions involved with hypophysiotropic, autonomic, limbic and extrapyramidal functions.

Original language	English (US)
Pages (from-to)	135-140
Number of pages	6
Journal	Brain Research
Volume	514
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(90)90445-H
State	Published - Apr 23 1990

Keywords

Cytokine
Hippocampus
Hypothalamus
Immunocytochemistry
Interleukin-1
Olfactory tubercle

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(90)90445-H

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title = "Immunoreactive interleukin-1β localization in the rat forebrain",

abstract = "To determine whether the cytokine, interleukin-1β, is present in the rat brain as has been reported in human brain, immunocytochemical studies were performed using an antiserum that recognizes recombinant, rat IL-1β. Immunoreaction product was present in the periventricular and medial hypothalamus, mossy fiber distribution in the hippocampus and olfactory tubercle. These studies demonstrate that IL-1β is part of a diffuse intrinsic neural system in the rat central nervous system, associated with regions involved with hypophysiotropic, autonomic, limbic and extrapyramidal functions.",

keywords = "Cytokine, Hippocampus, Hypothalamus, Immunocytochemistry, Interleukin-1, Olfactory tubercle",

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T1 - Immunoreactive interleukin-1β localization in the rat forebrain

AU - Lechan, Ronald M.

AU - Toni, R.

AU - Clark, B. D.

AU - Cannon, J. G.

AU - Shaw, A. R.

AU - Dinarello, C. A.

AU - Reichlin, S.

PY - 1990/4/23

Y1 - 1990/4/23

N2 - To determine whether the cytokine, interleukin-1β, is present in the rat brain as has been reported in human brain, immunocytochemical studies were performed using an antiserum that recognizes recombinant, rat IL-1β. Immunoreaction product was present in the periventricular and medial hypothalamus, mossy fiber distribution in the hippocampus and olfactory tubercle. These studies demonstrate that IL-1β is part of a diffuse intrinsic neural system in the rat central nervous system, associated with regions involved with hypophysiotropic, autonomic, limbic and extrapyramidal functions.

AB - To determine whether the cytokine, interleukin-1β, is present in the rat brain as has been reported in human brain, immunocytochemical studies were performed using an antiserum that recognizes recombinant, rat IL-1β. Immunoreaction product was present in the periventricular and medial hypothalamus, mossy fiber distribution in the hippocampus and olfactory tubercle. These studies demonstrate that IL-1β is part of a diffuse intrinsic neural system in the rat central nervous system, associated with regions involved with hypophysiotropic, autonomic, limbic and extrapyramidal functions.

KW - Cytokine

KW - Hippocampus

KW - Hypothalamus

KW - Immunocytochemistry

KW - Interleukin-1

KW - Olfactory tubercle

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Immunoreactive interleukin-1β localization in the rat forebrain

Abstract

Keywords

ASJC Scopus subject areas

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