Immunoreactive interleukin-1β localization in the rat forebrain

Ronald M. Lechan, R. Toni, B. D. Clark, J. G. Cannon, A. R. Shaw, C. A. Dinarello, S. Reichlin

Research output: Contribution to journalArticlepeer-review

336 Scopus citations


To determine whether the cytokine, interleukin-1β, is present in the rat brain as has been reported in human brain, immunocytochemical studies were performed using an antiserum that recognizes recombinant, rat IL-1β. Immunoreaction product was present in the periventricular and medial hypothalamus, mossy fiber distribution in the hippocampus and olfactory tubercle. These studies demonstrate that IL-1β is part of a diffuse intrinsic neural system in the rat central nervous system, associated with regions involved with hypophysiotropic, autonomic, limbic and extrapyramidal functions.

Original languageEnglish (US)
Pages (from-to)135-140
Number of pages6
JournalBrain Research
Issue number1
StatePublished - Apr 23 1990


  • Cytokine
  • Hippocampus
  • Hypothalamus
  • Immunocytochemistry
  • Interleukin-1
  • Olfactory tubercle

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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