TY - JOUR
T1 - Impact of early hypothalamic-pituitary-gonadal axis maturation on prostate cancer
T2 - Cross-sectional analysis of a Veterans affairs cohort
AU - Khadir, Rimaz M.
AU - Sayyid, Rashid K.
AU - Matthews, Brian
AU - King, Sherita A.
AU - Terris, Martha K.
N1 - Publisher Copyright:
© Translational Andrology and Urology. All rights reserved.
PY - 2021/8
Y1 - 2021/8
N2 - Background: It has been hypothesized that earlier onset of puberty, and thus a more prolonged exposure to high androgen levels, increases risk of prostate cancer development. Our objective was to determine whether earlier age of first shave and height, as surrogates of pubertal onset, were associated with risk of prostate cancer diagnosis. Methods: A prospectively collected outcomes registry of patients presenting for a prostate biopsy at the Charlie Norwood Veterans Affair Medical Center in Augusta, GA between July 1995 and June 2016 was utilized. The associations between age of first shave and height, each, and risks of a positive prostate biopsy, high grade cancer, and high volume disease were evaluated using univariable and multivariable logistic regression analysis, controlling for baseline patient demographic and oncologic characteristics. Results: Our cohort included 2, 456 patients. Biopsies were positive in 1, 257 (51.2%) patients, of whom 293 (23.3%) and 407 (32.4%) had high grade and volume disease, respectively. Median age of first shave was 17.0 years (interquartile range 16.0-19.0) and height was 177.7 cm (172.8-182.9). On multivariable analysis, later of age of first shave was significantly associated with increased odds of a positive prostate biopsy (odds ratio for >18 versus <16 years: 5.34, P=0.02) and taller patients had significantly increased odds of high grade cancer (odds ratio for 175-180 versus <175 cm: 7.46, P=0.037). Conclusions: Amongst patients presenting for a prostate biopsy, those with a later age of first shave and taller height have an increased risk of a positive prostate biopsy and high grade prostate cancer, respectively.
AB - Background: It has been hypothesized that earlier onset of puberty, and thus a more prolonged exposure to high androgen levels, increases risk of prostate cancer development. Our objective was to determine whether earlier age of first shave and height, as surrogates of pubertal onset, were associated with risk of prostate cancer diagnosis. Methods: A prospectively collected outcomes registry of patients presenting for a prostate biopsy at the Charlie Norwood Veterans Affair Medical Center in Augusta, GA between July 1995 and June 2016 was utilized. The associations between age of first shave and height, each, and risks of a positive prostate biopsy, high grade cancer, and high volume disease were evaluated using univariable and multivariable logistic regression analysis, controlling for baseline patient demographic and oncologic characteristics. Results: Our cohort included 2, 456 patients. Biopsies were positive in 1, 257 (51.2%) patients, of whom 293 (23.3%) and 407 (32.4%) had high grade and volume disease, respectively. Median age of first shave was 17.0 years (interquartile range 16.0-19.0) and height was 177.7 cm (172.8-182.9). On multivariable analysis, later of age of first shave was significantly associated with increased odds of a positive prostate biopsy (odds ratio for >18 versus <16 years: 5.34, P=0.02) and taller patients had significantly increased odds of high grade cancer (odds ratio for 175-180 versus <175 cm: 7.46, P=0.037). Conclusions: Amongst patients presenting for a prostate biopsy, those with a later age of first shave and taller height have an increased risk of a positive prostate biopsy and high grade prostate cancer, respectively.
KW - Biopsy
KW - Prostatic neoplasms
KW - Puberty
KW - Testosterone
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U2 - 10.21037/tau-21-433
DO - 10.21037/tau-21-433
M3 - Article
AN - SCOPUS:85113478763
SN - 2223-4683
VL - 10
SP - 3368
EP - 3374
JO - Translational Andrology and Urology
JF - Translational Andrology and Urology
IS - 8
ER -