Impact of obesity and insulin resistance on vasomotor tone: Nitric oxide and beyond

Research output: Contribution to journalShort surveypeer-review

35 Scopus citations


1. Obesity is rapidly increasing in Western populations, driving a parallel increase in hypertension, diabetes and vascular disease. Prior to the development of overt diabetes or hypertension, obese patients spend years in a state of progressive insulin resistance and metabolic disease. Mounting evidence suggests that this insulin-resistant state has deleterious effects on the control of blood flow, thus placing organ systems at a higher risk for end-organ damage and increasing cardiovascular mortality. 2. The purpose of the present review is to examine the current literature on the effects of obesity and insulin resistance on the acute control of vascular tone. Effects on nitric oxide (NO)-mediated control of vascular tone are particularly examined with regard to proximal causes and distal mechanisms of the impaired NO-mediation of vasodilation. 3. Finally, novel pathways of impaired control of perfusion are summarized from the recent literature to identify new avenues of exploring impaired vascular function in patients with metabolic disease.

Original languageEnglish (US)
Pages (from-to)407-414
Number of pages8
JournalClinical and Experimental Pharmacology and Physiology
Issue number5-6
StatePublished - May 2006


  • Adrenergic
  • Angiotensin II
  • Endothelin
  • Endothelium
  • Insulin resistance
  • Sympathetic

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)


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