TY - JOUR
T1 - Impacts of environmental factors on head and neck cancer pathogenesis and progression
AU - Miranda-Galvis, Marisol
AU - Loveless, Reid
AU - Kowalski, Luiz Paulo
AU - Teng, Yong
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/2
Y1 - 2021/2
N2 - Epidemiological and clinical studies over the past two decades have provided strong evidence that genetic elements interacting with environmental components can individually and col-lectively influence one’s susceptibility to cancer. In addition to tumorigenic properties, numerous environmental factors, such as nutrition, chemical carcinogens, and tobacco/alcohol consumption, possess pro-invasive and pro-metastatic cancer features. In contrast to traditional cancer treatment, modern therapeutics not only take into account an individual’s genetic makeup but also consider gene–environment interactions. The current review sharpens the focus by elaborating on the impact that environmental factors have on the pathogenesis and progression of head and neck cancer and the underlying molecular mechanisms involved. Recent advances, challenges, and future perspec-tives in this area of research are also discussed. Inhibiting key environmental drivers of tumor progression should yield survival benefits for patients at any stage of head and neck cancer.
AB - Epidemiological and clinical studies over the past two decades have provided strong evidence that genetic elements interacting with environmental components can individually and col-lectively influence one’s susceptibility to cancer. In addition to tumorigenic properties, numerous environmental factors, such as nutrition, chemical carcinogens, and tobacco/alcohol consumption, possess pro-invasive and pro-metastatic cancer features. In contrast to traditional cancer treatment, modern therapeutics not only take into account an individual’s genetic makeup but also consider gene–environment interactions. The current review sharpens the focus by elaborating on the impact that environmental factors have on the pathogenesis and progression of head and neck cancer and the underlying molecular mechanisms involved. Recent advances, challenges, and future perspec-tives in this area of research are also discussed. Inhibiting key environmental drivers of tumor progression should yield survival benefits for patients at any stage of head and neck cancer.
KW - Anticancer
KW - Environmental factors
KW - Head and neck cancer
KW - Metastasis
KW - Modern therapy
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U2 - 10.3390/cells10020389
DO - 10.3390/cells10020389
M3 - Review article
C2 - 33668576
AN - SCOPUS:85102681925
SN - 2073-4409
VL - 10
SP - 1
EP - 16
JO - Cells
JF - Cells
IS - 2
M1 - 389
ER -