Impaired pressure natriuresis in obese youths

Paule Barbeau, Mark S. Litaker, Gregory A. Harshfield

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Objective: To compare the response and recovery of blood pressure (BP) and sodium excretion (UNaV) in response to a behavioral stressor in overweight/obese and lean adolescents. Research Methods and Procedures: Twenty-five lean (12% to 20% body fat) and 59 overweight/obese (>25% body fat) normotensive adolescents were provided all meals for 3 days (average sodium intake, 4000 ± 200 mg/d), before performing the stressor on the third day. There was a 2-hour pre-stress rest, followed by a 1-hour stress (involving a video game task), and a 2-hour recovery. Percentage of body fat was obtained from DXA. UNaV was measured hourly, whereas systolic BP and diastolic BP measurements were obtained at 15-minute intervals, and averaged for each 1-hour period. Results: There was no significant difference between the lean and overweight/obese group for the response of systolic BP and diastolic BP (group by time interaction, p = 0.60 and p = 0.64, respectively). However, the lean group had a significantly greater increase in UNaV in response to the stressor compared with the overweight/obese group (p = 0.02). UNaV remained elevated compared with baseline in both groups at the 1-hour (p < 0.0001) and 2-hour (p ≤ 0.0001) post-time points. Furthermore, there was a tendency for a larger number of sodium retainers in the overweight/obese group compared with the lean group (39.0% vs. 20.0%; χ2 = 2.85, df = 1, p = 0.09). Discussion: This study provided evidence that sodium regulation was impaired during a behavioral stress in overweight/obese individuals compared with lean individuals.

Original languageEnglish (US)
Pages (from-to)745-751
Number of pages7
JournalObesity Research
Issue number6
StatePublished - 2003
Externally publishedYes


  • Blood pressure
  • Hypertension
  • Salt sensitivity
  • Sodium regulation
  • Youth

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Public Health, Environmental and Occupational Health


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