TY - JOUR
T1 - In vitro evidence for the protective role of sida rhomboidea. Roxb extract against LDL oxidation and oxidized ldl-induced apoptosis in human monocyte-derived macrophages
AU - Thounaojam, Menaka C.
AU - Jadeja, Ravirajsinh N.
AU - Devkar, Ranjisinh V.
AU - Ramachandran, A. V.
N1 - Funding Information:
Acknowledgments Authors are grateful to UGC-New Delhi for providing UGC-RFSMS fellowship to M.C.T and R.N.J. Kind help of Mr. Tribhuvan Bind (Advanced Instrumentation Research facility, New Delhi) for flow cytometry analysis and Dr. K S Rajput and, Dr. Hemendra Vekaria (The M S University of Baroda) for Florescence microscopy analysis are also acknowledged.
PY - 2011/6
Y1 - 2011/6
N2 - The present study was undertaken to evaluate protective role of S. rhomboidea. Roxb (SR) leaf extract against in vitro low-density lipoprotein (LDL) oxidation and oxidized LDL (Ox-LDL) induced macrophage apoptosis. Copper and cell-mediated LDL oxidation, Ox-LDL-induced peroxyl radical generation, mitochondrial activity, and apoptosis in human monocyte-derived macrophages (HMDMs) were assessed in presence of SR extract. Results clearly indicated that SR was capable of reducing LDL oxidation and formation of intermediary oxidation products. Also, SR successfully attenuated peroxyl radical formation, mitochondrial dysfunction, nuclear condensation, and apoptosis in Ox-LDL-exposed HMDMs. This scientific report is the first detailed investigation that establishes anti-atherosclerotic potential of SR extract.
AB - The present study was undertaken to evaluate protective role of S. rhomboidea. Roxb (SR) leaf extract against in vitro low-density lipoprotein (LDL) oxidation and oxidized LDL (Ox-LDL) induced macrophage apoptosis. Copper and cell-mediated LDL oxidation, Ox-LDL-induced peroxyl radical generation, mitochondrial activity, and apoptosis in human monocyte-derived macrophages (HMDMs) were assessed in presence of SR extract. Results clearly indicated that SR was capable of reducing LDL oxidation and formation of intermediary oxidation products. Also, SR successfully attenuated peroxyl radical formation, mitochondrial dysfunction, nuclear condensation, and apoptosis in Ox-LDL-exposed HMDMs. This scientific report is the first detailed investigation that establishes anti-atherosclerotic potential of SR extract.
KW - Atheorsclerosis
KW - LDL oxidation
KW - Macrophage apoptosis
KW - Oxidative stress
KW - S. rhomboidea. Roxb
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U2 - 10.1007/s12012-011-9110-6
DO - 10.1007/s12012-011-9110-6
M3 - Article
C2 - 21384160
AN - SCOPUS:79958040996
SN - 1530-7905
VL - 11
SP - 168
EP - 179
JO - Cardiovascular Toxicology
JF - Cardiovascular Toxicology
IS - 2
ER -