Induction of fully stabilized cortical bone defects to study intramembranous bone regeneration

Meghan Elizabeth McGee Lawrence; David F. Razidlo

doi:10.1007/978-1-4939-1619-1_14

Induction of fully stabilized cortical bone defects to study intramembranous bone regeneration

Meghan Elizabeth McGee Lawrence, David F. Razidlo

Cellular Biology and Anatomy

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Abstract

Bone is a regenerative tissue with an innate ability to self-remodel in response to environmental stimuli and the need to repair damage. Rodent models of fracture healing, and in particular genetic mouse models, can be used to study the contributions of specific molecular switches to skeletal repair, as well as to recreate and exacerbate biological development and repair mechanisms in postnatal skeletons. Here, we describe methodology for producing fully stabilized, single-cortex defects in mouse femurs to study mechanisms of intramembranous bone regeneration.

Original language	English (US)
Title of host publication	Osteoporosis and Osteoarthritis
Publisher	Springer New York
Pages	183-192
Number of pages	10
ISBN (Electronic)	9781493916191
ISBN (Print)	9781493916184
DOIs	https://doi.org/10.1007/978-1-4939-1619-1_14
State	Published - Oct 20 2014

Keywords

Fracture healing
Intramembranous bone formation
Mouse model
Stabilized defect repair

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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10.1007/978-1-4939-1619-1_14

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abstract = "Bone is a regenerative tissue with an innate ability to self-remodel in response to environmental stimuli and the need to repair damage. Rodent models of fracture healing, and in particular genetic mouse models, can be used to study the contributions of specific molecular switches to skeletal repair, as well as to recreate and exacerbate biological development and repair mechanisms in postnatal skeletons. Here, we describe methodology for producing fully stabilized, single-cortex defects in mouse femurs to study mechanisms of intramembranous bone regeneration.",

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AU - Razidlo, David F.

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N2 - Bone is a regenerative tissue with an innate ability to self-remodel in response to environmental stimuli and the need to repair damage. Rodent models of fracture healing, and in particular genetic mouse models, can be used to study the contributions of specific molecular switches to skeletal repair, as well as to recreate and exacerbate biological development and repair mechanisms in postnatal skeletons. Here, we describe methodology for producing fully stabilized, single-cortex defects in mouse femurs to study mechanisms of intramembranous bone regeneration.

AB - Bone is a regenerative tissue with an innate ability to self-remodel in response to environmental stimuli and the need to repair damage. Rodent models of fracture healing, and in particular genetic mouse models, can be used to study the contributions of specific molecular switches to skeletal repair, as well as to recreate and exacerbate biological development and repair mechanisms in postnatal skeletons. Here, we describe methodology for producing fully stabilized, single-cortex defects in mouse femurs to study mechanisms of intramembranous bone regeneration.

KW - Fracture healing

KW - Intramembranous bone formation

KW - Mouse model

KW - Stabilized defect repair

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BT - Osteoporosis and Osteoarthritis

PB - Springer New York

ER -

Induction of fully stabilized cortical bone defects to study intramembranous bone regeneration

Abstract

Keywords

ASJC Scopus subject areas

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