TY - JOUR
T1 - Inflammation, Proinflammatory Mediators and Myocardial Ischemia-reperfusion Injury
AU - Vinten-Johansen, Jakob
AU - Jiang, Rong
AU - Reeves, James G.
AU - Mykytenko, James
AU - Deneve, Jeremiah
AU - Jobe, Lynetta J.
N1 - Funding Information:
The authors thank the Carlyle Fraser Heart Center Foundation for their continued support of the research effort.
PY - 2007/2
Y1 - 2007/2
N2 - Ischemic myocardium must be reperfused to terminate the ischemic event; otherwise the entire myocardium involved in the area at risk will not survive. However, there is a cost to reperfusion that may offset the intended clinical benefits of minimizing infarct size, postischemic endothelial and microvascular damage, blood flow defects, and contractile dysfunction. There are many contributors to this reperfusion injury. Targeting only one factor in the complex web of reperfusion injury is not effective because the untargeted mechanisms induce injury. An integrated strategy of reducing reperfusion injury in the catheterization laboratory involves controlling both the conditions and the composition of the reperfusate. Mechanical interventions such as gradually restoring blood flow or applying postconditioning may be used independently in or conjunction with various cardioprotective pharmaceuticals in an integrated strategy of reperfusion therapeutics to reduce postischemic injury.
AB - Ischemic myocardium must be reperfused to terminate the ischemic event; otherwise the entire myocardium involved in the area at risk will not survive. However, there is a cost to reperfusion that may offset the intended clinical benefits of minimizing infarct size, postischemic endothelial and microvascular damage, blood flow defects, and contractile dysfunction. There are many contributors to this reperfusion injury. Targeting only one factor in the complex web of reperfusion injury is not effective because the untargeted mechanisms induce injury. An integrated strategy of reducing reperfusion injury in the catheterization laboratory involves controlling both the conditions and the composition of the reperfusate. Mechanical interventions such as gradually restoring blood flow or applying postconditioning may be used independently in or conjunction with various cardioprotective pharmaceuticals in an integrated strategy of reperfusion therapeutics to reduce postischemic injury.
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U2 - 10.1016/j.hoc.2006.11.010
DO - 10.1016/j.hoc.2006.11.010
M3 - Review article
C2 - 17258123
AN - SCOPUS:33846506801
SN - 0889-8588
VL - 21
SP - 123
EP - 145
JO - Hematology/Oncology Clinics of North America
JF - Hematology/Oncology Clinics of North America
IS - 1
ER -