Influence of Coffee on Fluoride Metabolism in Rats

J. T. Chan, C. C. Qui, G. M. Whitford, J. G. Weatherred

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Concomitant intragastric administration of sodium fluoride and coffee resulted in a significantly higher (P < 0.01) plasma fluoride level than intake of the same amount of fluoride with water. The same result was obtained when coffee was substituted with an equivalent amount of caffeine. Comparison of plasma fluoride levels by total area under the curve of plasma fluoride concentration versus time indicated an almost 2-fold difference. Although the mechanism(s) is not known, it appears that caffeine is responsible for the present observation. This finding could help explain the variations in the incidence of dental fluorosis among people living in optimally fluoridated communities.

Original languageEnglish (US)
Pages (from-to)43-47
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number1
StatePublished - May 1990
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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