Influence of the nature of quantum dot surface cations on interactions with DNA

Rahina Mahtab; Sheldon M. Sealey; Simona E. Hunyadi; Brian Kinard; Tyler Ray; Catherine J. Murphy

doi:10.1016/j.jinorgbio.2006.11.019

Influence of the nature of quantum dot surface cations on interactions with DNA

Rahina Mahtab, Sheldon M. Sealey, Simona E. Hunyadi, Brian Kinard, Tyler Ray, Catherine J. Murphy

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Quantum dots are semiconductor nanoparticles that are ∼1-10 nm in diameter, similar to small proteins, and their photoluminescence is sensitive to the presence and nature of adsorbates. We have deployed these nanomaterials as luminescent probes of DNA structure. Sequence dependent conformational flexibility of DNA is of great interest due to its implications for drug-DNA and DNA-protein interactions. The counterion atmosphere surrounding DNA plays an important role in its structure, dynamics, and packaging. In this paper, we investigate the effect that various monovalent and divalent cations have on the binding of 4.5 nm CdS quantum dots to oligonucleotides that have sequence-directed intrinsic structure.

Original language	English (US)
Pages (from-to)	559-564
Number of pages	6
Journal	Journal of Inorganic Biochemistry
Volume	101
Issue number	4
DOIs	https://doi.org/10.1016/j.jinorgbio.2006.11.019
State	Published - Apr 2007

Keywords

CdS
DNA
Nanoparticle
Oligonucleotides
Photoluminescence
Quantum dots

ASJC Scopus subject areas

Biochemistry
Inorganic Chemistry

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10.1016/j.jinorgbio.2006.11.019

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title = "Influence of the nature of quantum dot surface cations on interactions with DNA",

abstract = "Quantum dots are semiconductor nanoparticles that are ∼1-10 nm in diameter, similar to small proteins, and their photoluminescence is sensitive to the presence and nature of adsorbates. We have deployed these nanomaterials as luminescent probes of DNA structure. Sequence dependent conformational flexibility of DNA is of great interest due to its implications for drug-DNA and DNA-protein interactions. The counterion atmosphere surrounding DNA plays an important role in its structure, dynamics, and packaging. In this paper, we investigate the effect that various monovalent and divalent cations have on the binding of 4.5 nm CdS quantum dots to oligonucleotides that have sequence-directed intrinsic structure.",

keywords = "CdS, DNA, Nanoparticle, Oligonucleotides, Photoluminescence, Quantum dots",

author = "Rahina Mahtab and Sealey, {Sheldon M.} and Hunyadi, {Simona E.} and Brian Kinard and Tyler Ray and Murphy, {Catherine J.}",

note = "Funding Information: This work was supported by the National Science Foundation under Grant No. EPS-0447660 to the South Carolina Research Authority. S.M.S., T.R., and B.K. are undergraduates who presented portions of this work at the annual meeting of the South Carolina Academy of Sciences in March 2006.",

year = "2007",

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doi = "10.1016/j.jinorgbio.2006.11.019",

language = "English (US)",

volume = "101",

pages = "559--564",

journal = "Journal of Inorganic Biochemistry",

issn = "0162-0134",

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AU - Mahtab, Rahina

AU - Sealey, Sheldon M.

AU - Hunyadi, Simona E.

AU - Kinard, Brian

AU - Ray, Tyler

AU - Murphy, Catherine J.

N1 - Funding Information: This work was supported by the National Science Foundation under Grant No. EPS-0447660 to the South Carolina Research Authority. S.M.S., T.R., and B.K. are undergraduates who presented portions of this work at the annual meeting of the South Carolina Academy of Sciences in March 2006.

PY - 2007/4

Y1 - 2007/4

N2 - Quantum dots are semiconductor nanoparticles that are ∼1-10 nm in diameter, similar to small proteins, and their photoluminescence is sensitive to the presence and nature of adsorbates. We have deployed these nanomaterials as luminescent probes of DNA structure. Sequence dependent conformational flexibility of DNA is of great interest due to its implications for drug-DNA and DNA-protein interactions. The counterion atmosphere surrounding DNA plays an important role in its structure, dynamics, and packaging. In this paper, we investigate the effect that various monovalent and divalent cations have on the binding of 4.5 nm CdS quantum dots to oligonucleotides that have sequence-directed intrinsic structure.

AB - Quantum dots are semiconductor nanoparticles that are ∼1-10 nm in diameter, similar to small proteins, and their photoluminescence is sensitive to the presence and nature of adsorbates. We have deployed these nanomaterials as luminescent probes of DNA structure. Sequence dependent conformational flexibility of DNA is of great interest due to its implications for drug-DNA and DNA-protein interactions. The counterion atmosphere surrounding DNA plays an important role in its structure, dynamics, and packaging. In this paper, we investigate the effect that various monovalent and divalent cations have on the binding of 4.5 nm CdS quantum dots to oligonucleotides that have sequence-directed intrinsic structure.

KW - CdS

KW - DNA

KW - Nanoparticle

KW - Oligonucleotides

KW - Photoluminescence

KW - Quantum dots

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JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

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ER -

Influence of the nature of quantum dot surface cations on interactions with DNA

Abstract

Keywords

ASJC Scopus subject areas

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