Influence of the nature of quantum dot surface cations on interactions with DNA

Rahina Mahtab, Sheldon M. Sealey, Simona E. Hunyadi, Brian Kinard, Tyler Ray, Catherine J. Murphy

    Research output: Contribution to journalArticlepeer-review

    23 Scopus citations


    Quantum dots are semiconductor nanoparticles that are ∼1-10 nm in diameter, similar to small proteins, and their photoluminescence is sensitive to the presence and nature of adsorbates. We have deployed these nanomaterials as luminescent probes of DNA structure. Sequence dependent conformational flexibility of DNA is of great interest due to its implications for drug-DNA and DNA-protein interactions. The counterion atmosphere surrounding DNA plays an important role in its structure, dynamics, and packaging. In this paper, we investigate the effect that various monovalent and divalent cations have on the binding of 4.5 nm CdS quantum dots to oligonucleotides that have sequence-directed intrinsic structure.

    Original languageEnglish (US)
    Pages (from-to)559-564
    Number of pages6
    JournalJournal of Inorganic Biochemistry
    Issue number4
    StatePublished - Apr 2007


    • CdS
    • DNA
    • Nanoparticle
    • Oligonucleotides
    • Photoluminescence
    • Quantum dots

    ASJC Scopus subject areas

    • Biochemistry
    • Inorganic Chemistry


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