Influence of Vitamin D on Periodontal Inflammation: A Review

Mohamed M. Meghil; Christopher W. Cutler

doi:10.3390/pathogens12091180

Influence of Vitamin D on Periodontal Inflammation: A Review

Mohamed M. Meghil, Christopher W. Cutler

Periodontics

Research output: Contribution to journal › Review article › peer-review

Abstract

The active form of vitamin D is the hormonally active 1,25(OH)₂D₃ (Vit D) vitamin, which plays an important role in bone biology and host immunity. The vitamin D receptor (VDR) is a nuclear ligand-dependent transcription factor expressed by many cells. Ligation of VDR by VitD regulates a wide plethora of genes and physiologic functions through the formation of the complex Vit D-VDR signaling cascade. The influence of Vit D-VDR signaling in host immune response to microbial infection has been of interest to many researchers. This is particularly important in oral health and diseases, as oral mucosa is exposed to a complex microbiota, with certain species capable of causing disruption to immune homeostasis. In this review, we focus on the immune modulatory roles of Vit D in the bone degenerative oral disease, periodontitis.

Original language	English (US)
Article number	1180
Journal	Pathogens
Volume	12
Issue number	9
DOIs	https://doi.org/10.3390/pathogens12091180
State	Published - Sep 2023

Keywords

gingivitis
immunology
periodontitis
vitamin D

ASJC Scopus subject areas

Immunology and Allergy
Molecular Biology
General Immunology and Microbiology
Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/pathogens12091180

Cite this

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title = "Influence of Vitamin D on Periodontal Inflammation: A Review",

abstract = "The active form of vitamin D is the hormonally active 1,25(OH)2D3 (Vit D) vitamin, which plays an important role in bone biology and host immunity. The vitamin D receptor (VDR) is a nuclear ligand-dependent transcription factor expressed by many cells. Ligation of VDR by VitD regulates a wide plethora of genes and physiologic functions through the formation of the complex Vit D-VDR signaling cascade. The influence of Vit D-VDR signaling in host immune response to microbial infection has been of interest to many researchers. This is particularly important in oral health and diseases, as oral mucosa is exposed to a complex microbiota, with certain species capable of causing disruption to immune homeostasis. In this review, we focus on the immune modulatory roles of Vit D in the bone degenerative oral disease, periodontitis.",

keywords = "gingivitis, immunology, periodontitis, vitamin D",

author = "Meghil, {Mohamed M.} and Cutler, {Christopher W.}",

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doi = "10.3390/pathogens12091180",

language = "English (US)",

volume = "12",

journal = "Pathogens",

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AU - Meghil, Mohamed M.

AU - Cutler, Christopher W.

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N2 - The active form of vitamin D is the hormonally active 1,25(OH)2D3 (Vit D) vitamin, which plays an important role in bone biology and host immunity. The vitamin D receptor (VDR) is a nuclear ligand-dependent transcription factor expressed by many cells. Ligation of VDR by VitD regulates a wide plethora of genes and physiologic functions through the formation of the complex Vit D-VDR signaling cascade. The influence of Vit D-VDR signaling in host immune response to microbial infection has been of interest to many researchers. This is particularly important in oral health and diseases, as oral mucosa is exposed to a complex microbiota, with certain species capable of causing disruption to immune homeostasis. In this review, we focus on the immune modulatory roles of Vit D in the bone degenerative oral disease, periodontitis.

AB - The active form of vitamin D is the hormonally active 1,25(OH)2D3 (Vit D) vitamin, which plays an important role in bone biology and host immunity. The vitamin D receptor (VDR) is a nuclear ligand-dependent transcription factor expressed by many cells. Ligation of VDR by VitD regulates a wide plethora of genes and physiologic functions through the formation of the complex Vit D-VDR signaling cascade. The influence of Vit D-VDR signaling in host immune response to microbial infection has been of interest to many researchers. This is particularly important in oral health and diseases, as oral mucosa is exposed to a complex microbiota, with certain species capable of causing disruption to immune homeostasis. In this review, we focus on the immune modulatory roles of Vit D in the bone degenerative oral disease, periodontitis.

KW - gingivitis

KW - immunology

KW - periodontitis

KW - vitamin D

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Influence of Vitamin D on Periodontal Inflammation: A Review

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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