The effects of halothane and ketamine on (1) serotonin (5-hydroxytryptamine; 5-HT) uptake and (2) paroxetine binding to the 5-HT transporter in neuronal membranes were determined in rat brain. Both anesthetics inhibited the uptake of [3H]5-HT by synaptosomes, but only ketamine affected binding of [3H]paroxetine to the 5-HT transporter. Saturation analysis indicated that ketamine inhibition of [3H]paroxetine binding was competitive (Ki = 18.8 μM). These results indicate that halothane and ketamine inhibit 5-HT transport by different mechanisms.
|Original language||English (US)|
|Number of pages||5|
|State||Published - Apr 20 1990|
- Serotonin receptor
- Serotonin uptake
ASJC Scopus subject areas