TY - JOUR
T1 - Insulin-like growth factor-1 (IGF-1) as predictor of cardiovascular mortality in heart failure patients
T2 - data from the T.O.S.CA. registry
AU - T.O.S.CA. Investigators
AU - De Giorgi, Alfredo
AU - Marra, Alberto Maria
AU - Iacoviello, Massimo
AU - Triggiani, Vincenzo
AU - Rengo, Giuseppe
AU - Cacciatore, Francesco
AU - Maiello, Ciro
AU - Limongelli, Giuseppe
AU - Masarone, Daniele
AU - Perticone, Francesco
AU - Filardi, Pasquale Perrone
AU - Paolillo, Stefania
AU - Mancini, Antonio
AU - Volterrani, Maurizio
AU - Vriz, Olga
AU - Castello, Roberto
AU - Passantino, Andrea
AU - Campo, Michela
AU - Modesti, Pietro Amedeo
AU - Salzano, Andrea
AU - D’Assante, Roberta
AU - Arcopinto, Michele
AU - Raparelli, Valeria
AU - Fabbian, Fabio
AU - Sciacqua, Angela
AU - Colao, Annamaria
AU - Suzuki, Toru
AU - Bossone, Eduardo
AU - Cittadini, Antonio
AU - Cittadini, A.
AU - ArcopintoSalzano, M. A.
AU - Saccà, L.
AU - Monti, M. G.
AU - Napoli, R.
AU - Matarazzo, M.
AU - Stagnaro, F. M.
AU - Schiavo, A.
AU - Valente, P.
AU - Ferrara, F.
AU - Russo, V.
AU - Malinconico, M.
AU - Citro, R.
AU - Guastalamacchia, E.
AU - Iacoviello, M.
AU - Leone, M.
AU - Cacciatore, F.
AU - Maiello, C.
AU - Amarelli, C.
AU - Mattucci, I.
AU - Carbone, L.
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/9/1
Y1 - 2022/9/1
N2 - Introduction: Data from the “Trattamento Ormonale nello Scompenso CArdiaco” (T.O.S.CA) registry showed that heart failure (HF) represents a complex clinical syndrome with different hormonal alterations. Renal failure represents a frequent complication in HF. We evaluated the relationship between renal function and insuline-like growth factor-1 (IGF-1) deficiency and its impact on cardiovascular mortality (CVM) in patients enrolled in the T.O.S.CA. registry. Methods: At the enrolment, all subjects underwent chemistry examinations, including circulating hormones and cardiovascular functional tests. COX regression analysis was used to evaluate factors related to CVM during the follow-up period in all populations, in high-risk patients and in the young-adult population. Also, we evaluate the effects of renal function on the CVM. Results: 337 patients (41 deceased) were analyzed. CVM was related to severe renal dysfunction (HR stages IV–V = 4.86), high-risk conditions (HR 2.25), serum IGF-1 (HR 0.42), and HF etiology (HR 5.85 and HR 1.63 for valvular and ischemic etiology, respectively). In high-risk patients, CVM was related to IGF-1 levels, severe renal dysfunction and valvular etiology, whereas in young patients CMV was related to the high-risk pattern and serum IGF-1 levels. Conclusions: Our study showed the clinical and prognostic utility of the IGF-1 assay in patients with HF.
AB - Introduction: Data from the “Trattamento Ormonale nello Scompenso CArdiaco” (T.O.S.CA) registry showed that heart failure (HF) represents a complex clinical syndrome with different hormonal alterations. Renal failure represents a frequent complication in HF. We evaluated the relationship between renal function and insuline-like growth factor-1 (IGF-1) deficiency and its impact on cardiovascular mortality (CVM) in patients enrolled in the T.O.S.CA. registry. Methods: At the enrolment, all subjects underwent chemistry examinations, including circulating hormones and cardiovascular functional tests. COX regression analysis was used to evaluate factors related to CVM during the follow-up period in all populations, in high-risk patients and in the young-adult population. Also, we evaluate the effects of renal function on the CVM. Results: 337 patients (41 deceased) were analyzed. CVM was related to severe renal dysfunction (HR stages IV–V = 4.86), high-risk conditions (HR 2.25), serum IGF-1 (HR 0.42), and HF etiology (HR 5.85 and HR 1.63 for valvular and ischemic etiology, respectively). In high-risk patients, CVM was related to IGF-1 levels, severe renal dysfunction and valvular etiology, whereas in young patients CMV was related to the high-risk pattern and serum IGF-1 levels. Conclusions: Our study showed the clinical and prognostic utility of the IGF-1 assay in patients with HF.
KW - Chronic heart failure
KW - Chronic renal failure
KW - Heart failure with reduced ejection fraction
KW - IGF-1 deficiency
KW - Multiple hormonal deficiency syndrome
UR - http://www.scopus.com/inward/record.url?scp=85132114666&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85132114666&partnerID=8YFLogxK
U2 - 10.1007/s11739-022-02980-4
DO - 10.1007/s11739-022-02980-4
M3 - Article
C2 - 35445917
AN - SCOPUS:85132114666
SN - 1828-0447
VL - 17
SP - 1651
EP - 1660
JO - Internal and Emergency Medicine
JF - Internal and Emergency Medicine
IS - 6
ER -