Interaction of impulsive pressures of cavitation bubbles with cell membranes during sonoporation

Tetsuya Kodama, Ken Ichiro Koshiyama, Yukio Tomita, Maiko Suzuki, Takeru Yano, Shigeo Fujikawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations


Ultrasound contrast agents (UCAs), are capable of enhancing non-invasive cytoplasmic molecular delivery in the presence of ultrasound. Collapse of UCAs may generate nano-scale cavitation bubbles, resulting in the transient permeabilization of the cell membrane. In the present study, we investigated the interaction of a cavitation bubble-induced shock wave with a cell membrane using acoustic theory and molecular dynamics (MD) simulation. From the theory, we obtained the shock wave propagation distance from the center of a cavitation bubble that would induce membrane damage. The MD simulation determined the relationship between the uptake of water molecules into the lipid bilayer and the shock wave. The interaction of the shock wave induced a structural change of the bilayer and subsequently increased the fluidity of each molecule. These changes in the bilayer due to shock waves may be an important factor in the use of UCAs to produce the transient membrane permeability during sonoporation.

Original languageEnglish (US)
Title of host publicationTHERAPEUTIC ULTRASOUND
Subtitle of host publication5th International Symposium on Therapeutic Ultrasound
Number of pages5
StatePublished - May 8 2006
EventTHERAPEUTIC ULTRASOUND: 5th International Symposium on Therapeutic Ultrasound - Boston, MA, United States
Duration: Oct 27 2005Oct 29 2005

Publication series

NameAIP Conference Proceedings
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616


ConferenceTHERAPEUTIC ULTRASOUND: 5th International Symposium on Therapeutic Ultrasound
Country/TerritoryUnited States
CityBoston, MA


  • Cytoplasm
  • Molecular delivery
  • Shockwave
  • Ultrasound

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Ecology
  • Plant Science
  • General Physics and Astronomy
  • Nature and Landscape Conservation


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