TY - JOUR
T1 - Interconnected Clinical and Social Risk Factors in Breast Cancer and Heart Failure
AU - Sinha, Arjun
AU - Bavishi, Avni
AU - Hibler, Elizabeth A.
AU - Yang, Eric H.
AU - Parashar, Susmita
AU - Okwuosa, Tochukwu
AU - DeCara, Jeanne M.
AU - Brown, Sherry Ann
AU - Guha, Avirup
AU - Sadler, Diego
AU - Khan, Sadiya S.
AU - Shah, Sanjiv J.
AU - Yancy, Clyde W.
AU - Akhter, Nausheen
N1 - Funding Information:
SS has received research grants from the National Institutes of Health (U54 HL160273, R01 HL107577, R01 HL127028, R01 HL140731, and R01 HL149423), Actelion, AstraZeneca, Corvia, Novartis, and Pfizer; and has received personal fees from Abbott, Actelion, AstraZeneca, Amgen, Aria CV, Axon Therapies, Bayer, Boehringer-Ingelheim, Boston Scientific, Bristol-Myers Squibb, Cardiora, Coridea, CVRx, Cyclerion, Cytokinetics, Edwards Lifesciences, Eidos, Eisai, Imara, Impulse Dynamics, Intellia, Ionis, Ironwood, Lilly, Merck, MyoKardia, Novartis, Novo Nordisk, Pfizer, Prothena, Regeneron, Rivus, Sanofi, Shifamed, Tenax, Tenaya, and United Therapeutics. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher Copyright:
Copyright © 2022 Sinha, Bavishi, Hibler, Yang, Parashar, Okwuosa, DeCara, Brown, Guha, Sadler, Khan, Shah, Yancy and Akhter.
PY - 2022/5/20
Y1 - 2022/5/20
N2 - Breast cancer and heart failure share several known clinical cardiovascular risk factors, including age, obesity, glucose dysregulation, cholesterol dysregulation, hypertension, atrial fibrillation and inflammation. However, to fully comprehend the complex interplay between risk of breast cancer and heart failure, factors attributed to both biological and social determinants of health must be explored in risk-assessment. There are several social factors that impede implementation of prevention strategies and treatment for breast cancer and heart failure prevention, including socioeconomic status, neighborhood disadvantage, food insecurity, access to healthcare, and social isolation. A comprehensive approach to prevention of both breast cancer and heart failure must include assessment for both traditional clinical risk factors and social determinants of health in patients to address root causes of lifestyle and modifiable risk factors. In this review, we examine clinical and social determinants of health in breast cancer and heart failure that are necessary to consider in the design and implementation of effective prevention strategies that altogether reduce the risk of both chronic diseases.
AB - Breast cancer and heart failure share several known clinical cardiovascular risk factors, including age, obesity, glucose dysregulation, cholesterol dysregulation, hypertension, atrial fibrillation and inflammation. However, to fully comprehend the complex interplay between risk of breast cancer and heart failure, factors attributed to both biological and social determinants of health must be explored in risk-assessment. There are several social factors that impede implementation of prevention strategies and treatment for breast cancer and heart failure prevention, including socioeconomic status, neighborhood disadvantage, food insecurity, access to healthcare, and social isolation. A comprehensive approach to prevention of both breast cancer and heart failure must include assessment for both traditional clinical risk factors and social determinants of health in patients to address root causes of lifestyle and modifiable risk factors. In this review, we examine clinical and social determinants of health in breast cancer and heart failure that are necessary to consider in the design and implementation of effective prevention strategies that altogether reduce the risk of both chronic diseases.
KW - breast cancer
KW - heart failure
KW - reverse cardio-oncology
KW - risk factors
KW - social determinants of health
UR - http://www.scopus.com/inward/record.url?scp=85139566298&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85139566298&partnerID=8YFLogxK
U2 - 10.3389/fcvm.2022.847975
DO - 10.3389/fcvm.2022.847975
M3 - Review article
AN - SCOPUS:85139566298
SN - 2297-055X
VL - 9
JO - Frontiers in Cardiovascular Medicine
JF - Frontiers in Cardiovascular Medicine
M1 - 847975
ER -
