Interleukin 1α increases serum leptin concentrations in humans

John E. Janik, Brendan D. Curti, Robert V. Considine, Helen C. Rager, Geraldine C. Powers, W. Gregory Alvord, John W. Smith, Barry L. Gause, William C. Kopp

Research output: Contribution to journalArticlepeer-review

218 Scopus citations


Leptin, the protein product of the ob gene, regulates appetite and body weight in animals. Endotexin and cytokines, induced by endotoxin, interleukin (IL) 1 and tumor necrosis factor, increase expression of leptin in mice and hamsters. We measured serum leptin concentrations in patients with cancer before and after administration of recombinant human IL-1α. Fourteen patients received IL-1α at one of three dose levels (0.03, 0.1, or 0.3 μg/kg · day) for 5 days. Serum leptin concentrations increased in all but two patients within 24 h after the first dose. The increase in leptin was correlated directly with IL-1α dose (P = 0.0030). Despite continued administration of IL-1α, serum leptin concentrations returned to pretreatment levels by day 5 of therapy. An increase in serum leptin concentrations may be one mechanism by which anorexia is induced by IL-1α. However, tachyphylaxis of the leptin response suggests that other mechanisms also are involved.

Original languageEnglish (US)
Pages (from-to)3084-3086
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Issue number9
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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