Interphotoreceptor retinoid-binding protein: biochemistry and molecular biology.

G. I. Liou, L. Geng, W. Baehr

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


Interphotoreceptor retinoid-binding protein (IRBP) is a recent and still somewhat enigmatic newcomer in the family of photoreceptor-specific proteins involved in vision. It has been isolated, characterized, cloned and sequenced from several species in less than a decade. Its extracellular localization and the increased amount of bound all-trans retinol following illumination are consistent with the proposed function of IRBP in extracellular transport or buffering of retinol and retinal isomers in the IPM. Its capacity to bind a great many other hydrophobic ligands, however, may indicate a multi-purpose function. Many questions concerning biosynthesis and processing, secretion, tertiary structure and ligand binding remain to be answered. Perhaps most interesting, from a molecular biology point of view, will be the regulation of transcription and tissue-specific expression of this photoreceptor protein, and possible involvement of its gene in human retinal degenerations. Constructs consisting of IRBP regulatory sequences and foreign antigens incorporated into the germ line of transgenic mice will help in the characterization of promoters and enhancer elements, while suppression of IRBP gene expression and its consequences may give us a more precise answer about IRBP function.

Original languageEnglish (US)
Pages (from-to)115-137
Number of pages23
JournalProgress in clinical and biological research
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Interphotoreceptor retinoid-binding protein: biochemistry and molecular biology.'. Together they form a unique fingerprint.

Cite this