Intracerebral Hemorrhage: Blood Components and Neurotoxicity

Neha Madangarli, Frederick Bonsack, Rajaneekar Dasari, Sangeetha Sukumari-Ramesh

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Intracerebral hemorrhage (ICH) is a subtype of stroke which is associated with the highest mortality and morbidity rates of all strokes. Although it is a major public health problem, there is no effective treatment for ICH. As a consequence of ICH, various blood components accumulate in the brain parenchyma and are responsible for much of the secondary brain damage and ICH-induced neurological deficits. Therefore, the strategies that could attenuate the blood component-induced neurotoxicity and improve hematoma resolution are highly needed. The present article provides an overview of blood-induced brain injury after ICH and emphasizes the need to conduct further studies elucidating the mechanisms of hematoma resolution after ICH.

Original languageEnglish (US)
JournalBrain Sciences
Issue number11
StatePublished - Nov 9 2019
Externally publishedYes


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