Intrinsic pituitary interleukin-1β is induced by bacterial lipopolysaccharide

James I. Koenig, Kenneth Snow, Burton D. Clark, Roberto Toni, Joseph G. Cannon, Alan R. Shaw, Charles A. Dinarello, Seymour Reichlin, Stephanie L. Lee, Ronald M. Lechan

Research output: Contribution to journalArticlepeer-review

164 Scopus citations


Using a specific antiserum recognizing recombinant rat interleukin-1β (IL-1β), immunoreactive material was localized to cytoplasmic granules in anterior pituitary endocrine cells and colocalized with TSH in thyrotropes. Authenticity was established by Northern blot hybridization using a specific rat IL-1β cRNA probe, revealing a 1.8-kilobase mRNA identical to that in the spleen. The marked increase in anterior pituitary IL-1β message after the administration of bacterial lipopolysaccharide, raises the possibility that IL-1β may be involved in paracrine or autocrine regulation of pituitary function during infectious challenge.

Original languageEnglish (US)
Pages (from-to)3053-3058
Number of pages6
Issue number6
StatePublished - Jun 1990
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology


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