Isolation of 5-Hydroxy-γ-lactams from a Classical 2-Aminopyrrole Synthesis

Nisaraporn Suthiwangcharoen, Andrew C. Bean, Minna Hassan, Cheryl K. Eidell, Chad E. Stephens

Research output: Contribution to journalArticlepeer-review


5-hydroxy-γ-lactams have been isolated as major byproducts from a classical 2-aminopyrrole synthesis involving condensation of an in situ prepared α-aminoketone with methyl cyanoacetate. The classical 2-aminopyrrole was obtained in very low yield, or not at all. One 5-hydroxy-γ-lactam was dehydrated to the known 5-methylene-γ-lactam in good yield using thionyl chloride.

Original languageEnglish (US)
Pages (from-to)1219-1222
Number of pages4
JournalJournal of Heterocyclic Chemistry
Issue number5
StatePublished - May 2018

ASJC Scopus subject areas

  • Organic Chemistry


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