Keeping neuronal activity in check: a novel role for α-synuclein serine-129 phosphorylation in the healthy brain

Danielle E. Mor

doi:10.1016/j.tibs.2024.02.006

Keeping neuronal activity in check: a novel role for α-synuclein serine-129 phosphorylation in the healthy brain

Danielle E. Mor

Neuroscience and Regenerative Medicine

Research output: Contribution to journal › Short survey › peer-review

Abstract

Phosphorylation of α-synuclein protein at serine-129 (Ser129P) is a widely used marker for disease pathology in neurodegenerative disorders termed synucleinopathies. In groundbreaking work by Parra-Rivas, Madhivanan et al., Ser129P was shown to facilitate the normal function of α-synuclein, bearing significant implications for the transition from a physiological to pathological state.

Original language	English (US)
Journal	Trends in Biochemical Sciences
DOIs	https://doi.org/10.1016/j.tibs.2024.02.006
State	Accepted/In press - 2024

Keywords

neuronal activity
phosphorylation
serine-129
α-synuclein

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/j.tibs.2024.02.006

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title = "Keeping neuronal activity in check: a novel role for α-synuclein serine-129 phosphorylation in the healthy brain",

abstract = "Phosphorylation of α-synuclein protein at serine-129 (Ser129P) is a widely used marker for disease pathology in neurodegenerative disorders termed synucleinopathies. In groundbreaking work by Parra-Rivas, Madhivanan et al., Ser129P was shown to facilitate the normal function of α-synuclein, bearing significant implications for the transition from a physiological to pathological state.",

keywords = "neuronal activity, phosphorylation, serine-129, α-synuclein",

author = "Mor, {Danielle E.}",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Ltd",

year = "2024",

doi = "10.1016/j.tibs.2024.02.006",

language = "English (US)",

journal = "Trends in Biochemical Sciences",

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AB - Phosphorylation of α-synuclein protein at serine-129 (Ser129P) is a widely used marker for disease pathology in neurodegenerative disorders termed synucleinopathies. In groundbreaking work by Parra-Rivas, Madhivanan et al., Ser129P was shown to facilitate the normal function of α-synuclein, bearing significant implications for the transition from a physiological to pathological state.

KW - neuronal activity

KW - phosphorylation

KW - serine-129

KW - α-synuclein

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DO - 10.1016/j.tibs.2024.02.006

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JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

ER -

Keeping neuronal activity in check: a novel role for α-synuclein serine-129 phosphorylation in the healthy brain

Abstract

Keywords

ASJC Scopus subject areas

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