Abstract
Phosphorylation of α-synuclein protein at serine-129 (Ser129P) is a widely used marker for disease pathology in neurodegenerative disorders termed synucleinopathies. In groundbreaking work by Parra-Rivas, Madhivanan et al., Ser129P was shown to facilitate the normal function of α-synuclein, bearing significant implications for the transition from a physiological to pathological state.
Original language | English (US) |
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Pages (from-to) | 382-383 |
Number of pages | 2 |
Journal | Trends in Biochemical Sciences |
Volume | 49 |
Issue number | 5 |
DOIs | |
State | Published - May 2024 |
Keywords
- neuronal activity
- phosphorylation
- serine-129
- α-synuclein
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology