Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA

D. Meruelo; R. Kornreich; A. Rossomando; C. Pampeno; A. Boral; J. L. Silver; J. Buxbaum; E. H. Weiss; J. J. Devlin; A. L. Mellor

doi:10.1073/pnas.83.12.4504

Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA

D. Meruelo, R. Kornreich, A. Rossomando, C. Pampeno, A. Boral, J. L. Silver, J. Buxbaum, E. H. Weiss, J. J. Devlin, A. L. Mellor

Infectious Disease

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Abstract

Transformation of murine thymocytes by radiation leukemia virus is associated with reduced expression of the class I antigens encoded in the major histocompatibility complex (MHC) and increased methylation and altered restriction enzyme patterns of MHC DNA. These changes may play a role in host susceptibility to virus-induced leukemogenesis and accord with the notion that viral genomes play a regulatory function when they integrate adjacent to histocompatibility genes.

Original language	English (US)
Pages (from-to)	4504-4508
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	83
Issue number	12
DOIs	https://doi.org/10.1073/pnas.83.12.4504
State	Published - 1986

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Meruelo, D., Kornreich, R., Rossomando, A., Pampeno, C., Boral, A., Silver, J. L., Buxbaum, J., Weiss, E. H., Devlin, J. J., & Mellor, A. L. (1986). Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA. Proceedings of the National Academy of Sciences of the United States of America, 83(12), 4504-4508. https://doi.org/10.1073/pnas.83.12.4504

Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA. / Meruelo, D.; Kornreich, R.; Rossomando, A. et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, No. 12, 1986, p. 4504-4508.

Research output: Contribution to journal › Article › peer-review

Meruelo, D, Kornreich, R, Rossomando, A, Pampeno, C, Boral, A, Silver, JL, Buxbaum, J, Weiss, EH, Devlin, JJ & Mellor, AL 1986, 'Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA', Proceedings of the National Academy of Sciences of the United States of America, vol. 83, no. 12, pp. 4504-4508. https://doi.org/10.1073/pnas.83.12.4504

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AU - Meruelo, D.

AU - Kornreich, R.

AU - Rossomando, A.

AU - Pampeno, C.

AU - Boral, A.

AU - Silver, J. L.

AU - Buxbaum, J.

AU - Weiss, E. H.

AU - Devlin, J. J.

AU - Mellor, A. L.

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Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA

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