Large-scale neural ensemble recording in the brains of freely behaving mice

Longnian Lin, Guifen Chen, Kun Xie, Kimberly A. Zaia, Shuqing Zhang, Joe Z. Tsien

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


With the availability of sophisticated genetic techniques, the mouse is a valuable mammalian model to study the molecular and cellular basis of cognitive behaviors. However, the small size of mice makes it difficult for a systematic investigation of activity patterns of neural networks in vivo. Here we report the development and construction of a high-density ensemble recording array with up to 128-recording channels that can be formatted as single electrodes, stereotrodes, or tetrodes. This high-density recording array is capable of recording from hundreds of individual neurons simultaneously in the hippocampus of the freely behaving mice. This large-scale in vivo ensemble recording techniques, once coupled with mouse genetics, should be valuable to the study of complex relationship between the genes, neural network, and cognitive behaviors.

Original languageEnglish (US)
Pages (from-to)28-38
Number of pages11
JournalJournal of Neuroscience Methods
Issue number1
StatePublished - Jul 15 2006
Externally publishedYes


  • CA1 region
  • Ensemble recording
  • Hippocampus
  • In vivo recording
  • Memory
  • Microdrive
  • Mouse
  • Startle
  • Stereotrode
  • Tetrode

ASJC Scopus subject areas

  • Neuroscience(all)


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