Leukocyte adhesion molecules in animal models of inflammatory bowel disease

Jesús Rivera-Nieves, Gezahegn Gorfu, Klaus Ley

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations


The dysregulated recruitment of leukocytes into the intestine is required for the initiation and maintenance of inflammatory bowel disease (IBD). Several families of molecules regulate the influx of these cells into sites of inflammation. Interference with some of these molecules has already shown efficacy in the clinics and antibodies that target the molecules involved have been approved by the FDA for use in Crohn's disease (CD), multiple sclerosis (i.e., natalizumab), and psoriasis (i.e., efalizumab). Here, we discuss basic aspects of the different families of relevant molecules and compile a large body of preclinical studies that supported the targeting of specific steps of the leukocyte adhesion cascade for therapeutic purposes in colitis and in novel models of CD-like ileitis.

Original languageEnglish (US)
Pages (from-to)1715-1735
Number of pages21
JournalInflammatory Bowel Diseases
Issue number12
StatePublished - 2008
Externally publishedYes


  • Adhesion cascade
  • IBD
  • Recruitment of leukocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Gastroenterology


Dive into the research topics of 'Leukocyte adhesion molecules in animal models of inflammatory bowel disease'. Together they form a unique fingerprint.

Cite this