TY - JOUR
T1 - Leukocyte adhesion to vascular endothelium
AU - Ley, K.
PY - 1992
Y1 - 1992
N2 - Leukocyte adhesion and emigration are controlled by soluble mediators and effected by various adhesion molecules. Currently, three major families of adhesion receptors are known to contribute to this process: integrins, vascular selectins, and immunoglobulin-like receptors. These adhesion systems are not additive and mutually replaceable, but appear to constitute a cascade of events. Leukocyte margination is followed by rolling, firm adhesion, emigration, and migration in the interstitial space. In addition, biomechanical parameters like leukocyte deformability and shear stress exerted by the flowing blood modulate the efficacy of adhesive interaction. This article briefly reviews the molecular nature, biologic regulation, and physiologic function of pertinent adhesion receptors.
AB - Leukocyte adhesion and emigration are controlled by soluble mediators and effected by various adhesion molecules. Currently, three major families of adhesion receptors are known to contribute to this process: integrins, vascular selectins, and immunoglobulin-like receptors. These adhesion systems are not additive and mutually replaceable, but appear to constitute a cascade of events. Leukocyte margination is followed by rolling, firm adhesion, emigration, and migration in the interstitial space. In addition, biomechanical parameters like leukocyte deformability and shear stress exerted by the flowing blood modulate the efficacy of adhesive interaction. This article briefly reviews the molecular nature, biologic regulation, and physiologic function of pertinent adhesion receptors.
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U2 - 10.1055/s-2007-1006736
DO - 10.1055/s-2007-1006736
M3 - Short survey
C2 - 1453376
AN - SCOPUS:0026469658
SN - 0743-684X
VL - 8
SP - 495
EP - 503
JO - Journal of Reconstructive Microsurgery
JF - Journal of Reconstructive Microsurgery
IS - 6
ER -