Lewy bodies contain beta-amyloid precursor proteins of Alzheimer's disease

Hiroyuki Arai, Virginia M.Y. Lee, William D. Hill, Barry D. Greenberg, John Q. Trojanowski

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


To assess the contribution of Alzheimer's disease amyloid proteins to cortical and substantia nigra Lewy bodies (LBs), regions of postmortem brain rich in intraneuronal LBs were examined immunohistochemically. Antibodies to epitopes in domains outside the amyloidogenic beta-amyloid peptide (BAP) in BAP precursor proteins (BAPPs) as well as to the BAP itself were used as probes. These studies showed that only BAPP epitopes outside the BAP were present in substantia nigral and cortical LBs. Thus, non-amyloidogenic domains of BAPPs may be associated with intraneuronal inclusions comprised of neurofilament proteins.

Original languageEnglish (US)
Pages (from-to)386-390
Number of pages5
JournalBrain Research
Issue number1-2
StatePublished - Jul 10 1992


  • Alzheimer's disease
  • Lewy body
  • Parkinson's disease
  • β-Amyloid precursor protein

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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