TY - JOUR
T1 - Loss of CCR2 expressing non-classical monocytes are associated with cognitive impairment in antiretroviral therapy-naïve HIV-infected Thais
AU - Ndhlovu, Lishomwa C.
AU - D'Antoni, Michelle L.
AU - Ananworanich, Jintanat
AU - Byron, Mary Margaret
AU - Chalermchai, Thep
AU - Sithinamsuwan, Pasiri
AU - Tipsuk, Somporn
AU - Ho, Erika
AU - Slike, Bonnie M.
AU - Schuetz, Alexandra
AU - Zhang, Guangxiang
AU - Agsalda-Garcia, Melissa
AU - Shiramizu, Bruce
AU - Shikuma, Cecilia M.
AU - Valcour, Victor
N1 - Funding Information:
We thank the SEARCH 011 participants and the SEARCH 011 study group. The SEARCH 011 study group includes: from SEARCH/TRCARC: Nittaya Phanuphak, Nitiya Chomchey, Eugene Kroon, Donn Colby, James Fletcher, Duanghathai Sutthichom, Somprartthana Rattanamanee, Peeriya Mangyu, Sasiwimol Ubolyam, Pacharin Eamyoung, Suwanna Puttamaswin and Putthachard Sangtawan; from Chulalongkorn University: Sukalya Lerdlum, Mantana Pothisri, Nijasri Charnnarong; from Phramongkutklao Medical Center: Yotin Chinvarun; from the Armed Forces Research Institute of Medical Sciences: Rapee Trichavaroj, Siriwat Akapirat, Weerawan Chuenarom, Boot Keawboon; from Taksin Hospital: Supunee Jirajariyavej. Akash Desai, Nicholas Huntchings, Lauren Wendelken and Katherine Clifford (UCSF). Research reported in this publication was supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health (NIH) under Award Number R01NS061696 . This work was also supported in part by NIH/NIMHD grant U54MD007584 , G12MD007601 and P20GM103466 . The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
Publisher Copyright:
© 2015 Elsevier B.V..
PY - 2015/11/15
Y1 - 2015/11/15
N2 - HIV DNA in monocytes has been linked to HIV-associated neurocognitive disorders (HAND), however, characterization of monocyte subsets associated with HAND remains unclear. We completed a prospective study of antiretroviral therapy-naïve, HIV-infected Thais, with varying degrees of cognitive impairment, compared to HIV-uninfected controls. Monocyte subsets' CCR2, CCR5 and CD163 expression were profiled and inflammatory markers in plasma and cerebrospinal fluid (CSF), measured. Lower numbers of CCR2+non-classical monocytes were associated with worse neuropsychological test performance (r=0.43, p=0.024). CCR2+non-classical monocyte count inversely correlated with CSF neopterin (r=-0.43, p=0.035) and plasma TNF-α levels (r=-0.40, p=0.041). These data benchmark CCR2+non-classical monocytes as an independent index of cognitive impairment.
AB - HIV DNA in monocytes has been linked to HIV-associated neurocognitive disorders (HAND), however, characterization of monocyte subsets associated with HAND remains unclear. We completed a prospective study of antiretroviral therapy-naïve, HIV-infected Thais, with varying degrees of cognitive impairment, compared to HIV-uninfected controls. Monocyte subsets' CCR2, CCR5 and CD163 expression were profiled and inflammatory markers in plasma and cerebrospinal fluid (CSF), measured. Lower numbers of CCR2+non-classical monocytes were associated with worse neuropsychological test performance (r=0.43, p=0.024). CCR2+non-classical monocyte count inversely correlated with CSF neopterin (r=-0.43, p=0.035) and plasma TNF-α levels (r=-0.40, p=0.041). These data benchmark CCR2+non-classical monocytes as an independent index of cognitive impairment.
KW - C-C chemokine receptor (CCR) CCR2
KW - CD163
KW - HIV-associated neurocognitive disorders (HAND)
KW - Monocytes
KW - Neopterin
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U2 - 10.1016/j.jneuroim.2015.08.020
DO - 10.1016/j.jneuroim.2015.08.020
M3 - Article
C2 - 26531691
AN - SCOPUS:84945543480
SN - 0165-5728
VL - 288
SP - 25
EP - 33
JO - Advances in Neuroimmunology
JF - Advances in Neuroimmunology
ER -
