Malignant rhabdoid tumor of the duodenum

Jeffrey R. Lee

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


A polypoid malignant rhabdoid tumor of the duodenum is presented. The pattern of metastatic spread in this 58-year-old man included multiple duodenal and small intestinal transmural tumor implants and a large peribronchial lymph node causing superior vena cava syndrome. Microscopically, the tumor was composed of a diffuse population of rhabdoid cells characterized by homogeneous globular cytoplasmic inclusions that tended to indent or displace eccentric, vesicular nuclei with nucleoli. No glandular features were noted. Immunohistochemical and ultrastructural evaluation revealed that these inclusions contained vimentin, an intermediate filament of the mesenchymal cytoskeleton. Phenotypic features of a rhabdoid tumor have been reported in 10 poorly differentiated malignancies of the gastrointestinal tract. This is the first case report of a malignant rhabdoid tumor of the small intestine. Regardless of the site of the lesion, tumors showing these features are generally associated with a poor prognosis.

Original languageEnglish (US)
Pages (from-to)25-30
Number of pages6
JournalAnnals of Diagnostic Pathology
Issue number1
StatePublished - 1998
Externally publishedYes


  • Duodenum
  • Rhabdoid
  • Vimentin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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