Maturation of dendritic cell precursors into IL12-producing DCs by J-LEAPS immunogens

Patricia R. Taylor; Christopher C. Paustian; Gary K. Koski; Daniel H. Zimmerman; Ken S. Rosenthal

doi:10.1016/j.cellimm.2010.01.003

Maturation of dendritic cell precursors into IL12-producing DCs by J-LEAPS immunogens

Patricia R. Taylor, Christopher C. Paustian, Gary K. Koski, Daniel H. Zimmerman, Ken S. Rosenthal

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

LEAPS (ligand epitope antigen presentation system) vaccines consist of a peptide containing a major histocompatibility antigen binding peptide conjugated to an immune cell binding ligand (ICBL) such as the 'J' peptide from beta-2-microglobulin. Treatment of monocytes, monocytes plus GMCSF, or monocytes plus GMCSF and IL4 with JgD (containing a peptide from gD of herpes simplex virus type 1) or JH (with a peptide from HIV p17 gag protein) was sufficient to promote their maturation into Interleukin 12 producing dendritic cells. JgD-dendritic cells supported allotypic activation of T cells to produce Th1-related cytokines.

Original language	English (US)
Pages (from-to)	1-5
Number of pages	5
Journal	Cellular Immunology
Volume	262
Issue number	1
DOIs	https://doi.org/10.1016/j.cellimm.2010.01.003
State	Published - 2010
Externally published	Yes

Keywords

Dendritic cell
Human
LEAPS
Monocyte
Vaccine

ASJC Scopus subject areas

Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cellimm.2010.01.003

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abstract = "LEAPS (ligand epitope antigen presentation system) vaccines consist of a peptide containing a major histocompatibility antigen binding peptide conjugated to an immune cell binding ligand (ICBL) such as the 'J' peptide from beta-2-microglobulin. Treatment of monocytes, monocytes plus GMCSF, or monocytes plus GMCSF and IL4 with JgD (containing a peptide from gD of herpes simplex virus type 1) or JH (with a peptide from HIV p17 gag protein) was sufficient to promote their maturation into Interleukin 12 producing dendritic cells. JgD-dendritic cells supported allotypic activation of T cells to produce Th1-related cytokines.",

keywords = "Dendritic cell, Human, LEAPS, Monocyte, Vaccine",

author = "Taylor, {Patricia R.} and Paustian, {Christopher C.} and Koski, {Gary K.} and Zimmerman, {Daniel H.} and Rosenthal, {Ken S.}",

year = "2010",

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T1 - Maturation of dendritic cell precursors into IL12-producing DCs by J-LEAPS immunogens

AU - Taylor, Patricia R.

AU - Paustian, Christopher C.

AU - Koski, Gary K.

AU - Zimmerman, Daniel H.

AU - Rosenthal, Ken S.

PY - 2010

Y1 - 2010

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AB - LEAPS (ligand epitope antigen presentation system) vaccines consist of a peptide containing a major histocompatibility antigen binding peptide conjugated to an immune cell binding ligand (ICBL) such as the 'J' peptide from beta-2-microglobulin. Treatment of monocytes, monocytes plus GMCSF, or monocytes plus GMCSF and IL4 with JgD (containing a peptide from gD of herpes simplex virus type 1) or JH (with a peptide from HIV p17 gag protein) was sufficient to promote their maturation into Interleukin 12 producing dendritic cells. JgD-dendritic cells supported allotypic activation of T cells to produce Th1-related cytokines.

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KW - Monocyte

KW - Vaccine

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Maturation of dendritic cell precursors into IL12-producing DCs by J-LEAPS immunogens

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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