TY - JOUR
T1 - Measurement of rat brain tumor kinetics using an intravascular MR contrast agent and DCE-MRI nested model selection
AU - Chwang, Wilson B.
AU - Jain, Rajan
AU - Bagher-Ebadian, Hassan
AU - Nejad-Davarani, Siamak P.
AU - Iskander, A. S.M.
AU - VanSlooten, Ashley
AU - Schultz, Lonni
AU - Arbab, Ali Syed
AU - Ewing, James R.
N1 - Publisher Copyright:
© 2014 Wiley Periodicals, Inc.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Purpose: Using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in a rat glioma model, and nested model selection (NMS), to compare estimates of the pharmacokinetic parameters vp, Ktrans, and ve for two different contrast agents (CAs)gadofosveset, which reversibly binds to human serum albumin, and gadopentetate dimeglumine, which does not.Materials and Methods: DCE-MRI studies were performed on nine Fisher 344 rats inoculated intracerebrally with 9L gliosarcoma cells using both gadofosveset and gadopentetate. The parameters vp, Ktrans, and ve were estimated using NMS.Results: Ktrans estimates using gadofosveset, compared to gadopentetate, differed in their means (gadofosveset 0.025 ± 0.008 min-1 vs. gadopentetate 0.046 ± 0.011 min-1; P = 0.0039). This difference notwithstanding, the intraclass correlation coefficient (ICC) for the two estimates of Ktrans showed nearly perfect linear dependence (ICC = 0.8479 by Pearson's r). Other estimates, ve (gadofosveset 22.7 ± 4.7% vs. gadopentetate 23.6 ± 5.6%; P = 0.4258) and vp (gadofosveset 1.5 ± 0.5% vs. gadopentetate 1.6 ± 0.4%; P = 0.25), were not different in their means between the two CAs, and there was almost perfect agreement for ve (ICC = 0.8798) and substantial agreement for vp (ICC = 0.7981) between the two CAs.Conclusion: Estimates of Ktrans were statistically different using gadofosveset and gadopentetate, whereas ve and vp were similar with two CAs. NMS produced robust estimates of pharmacokinetic parameters using DCE-MRI that show promise as important measures of tumor physiology and microenvironment.
AB - Purpose: Using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in a rat glioma model, and nested model selection (NMS), to compare estimates of the pharmacokinetic parameters vp, Ktrans, and ve for two different contrast agents (CAs)gadofosveset, which reversibly binds to human serum albumin, and gadopentetate dimeglumine, which does not.Materials and Methods: DCE-MRI studies were performed on nine Fisher 344 rats inoculated intracerebrally with 9L gliosarcoma cells using both gadofosveset and gadopentetate. The parameters vp, Ktrans, and ve were estimated using NMS.Results: Ktrans estimates using gadofosveset, compared to gadopentetate, differed in their means (gadofosveset 0.025 ± 0.008 min-1 vs. gadopentetate 0.046 ± 0.011 min-1; P = 0.0039). This difference notwithstanding, the intraclass correlation coefficient (ICC) for the two estimates of Ktrans showed nearly perfect linear dependence (ICC = 0.8479 by Pearson's r). Other estimates, ve (gadofosveset 22.7 ± 4.7% vs. gadopentetate 23.6 ± 5.6%; P = 0.4258) and vp (gadofosveset 1.5 ± 0.5% vs. gadopentetate 1.6 ± 0.4%; P = 0.25), were not different in their means between the two CAs, and there was almost perfect agreement for ve (ICC = 0.8798) and substantial agreement for vp (ICC = 0.7981) between the two CAs.Conclusion: Estimates of Ktrans were statistically different using gadofosveset and gadopentetate, whereas ve and vp were similar with two CAs. NMS produced robust estimates of pharmacokinetic parameters using DCE-MRI that show promise as important measures of tumor physiology and microenvironment.
KW - Contrast agent
KW - DCE-MRI
KW - Gadofosveset
KW - Gadopentetate
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U2 - 10.1002/jmri.24469
DO - 10.1002/jmri.24469
M3 - Article
C2 - 24421265
AN - SCOPUS:84913613760
SN - 1053-1807
VL - 40
SP - 1223
EP - 1229
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
IS - 5
ER -