Mechanisms by which diabetes increases cardiovascular disease

Christian A. Gleissner; Elena Galkina; Jerry L. Nadler; Klaus Ley

doi:10.1016/j.ddmec.2007.12.005

Mechanisms by which diabetes increases cardiovascular disease

Christian A. Gleissner, Elena Galkina, Jerry L. Nadler, Klaus Ley

Research output: Contribution to journal › Review article › peer-review

69 Scopus citations

Abstract

Diabetes mellitus is one of the major risk factors for cardiovascular disease which is the leading cause of death in the United States. Increasing prevalence of diabetes and diabetic atherosclerosis makes identification of molecular mechanisms by which diabetes promotes atherogenesis an important task. Targeting common pathways may ameliorate both diseases. This review focuses on well-known as well as newly discovered mechanisms which may represent promising therapeutic targets.

Original language	English (US)
Pages (from-to)	131-140
Number of pages	10
Journal	Drug Discovery Today: Disease Mechanisms
Volume	4
Issue number	3
DOIs	https://doi.org/10.1016/j.ddmec.2007.12.005
State	Published - Sep 2007
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ddmec.2007.12.005

Cite this

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title = "Mechanisms by which diabetes increases cardiovascular disease",

abstract = "Diabetes mellitus is one of the major risk factors for cardiovascular disease which is the leading cause of death in the United States. Increasing prevalence of diabetes and diabetic atherosclerosis makes identification of molecular mechanisms by which diabetes promotes atherogenesis an important task. Targeting common pathways may ameliorate both diseases. This review focuses on well-known as well as newly discovered mechanisms which may represent promising therapeutic targets.",

author = "Gleissner, {Christian A.} and Elena Galkina and Nadler, {Jerry L.} and Klaus Ley",

note = "Funding Information: This work was supported by the Deutsche Forschungsgemeinschaft (grant GL599/1-1 to C.A.G.), by NIH grant HL58108 (to K.L.), and by NIH grant HL55798 (to K.L. and J.L.N.).",

year = "2007",

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TY - JOUR

T1 - Mechanisms by which diabetes increases cardiovascular disease

AU - Gleissner, Christian A.

AU - Galkina, Elena

AU - Nadler, Jerry L.

AU - Ley, Klaus

N1 - Funding Information: This work was supported by the Deutsche Forschungsgemeinschaft (grant GL599/1-1 to C.A.G.), by NIH grant HL58108 (to K.L.), and by NIH grant HL55798 (to K.L. and J.L.N.).

PY - 2007/9

Y1 - 2007/9

N2 - Diabetes mellitus is one of the major risk factors for cardiovascular disease which is the leading cause of death in the United States. Increasing prevalence of diabetes and diabetic atherosclerosis makes identification of molecular mechanisms by which diabetes promotes atherogenesis an important task. Targeting common pathways may ameliorate both diseases. This review focuses on well-known as well as newly discovered mechanisms which may represent promising therapeutic targets.

AB - Diabetes mellitus is one of the major risk factors for cardiovascular disease which is the leading cause of death in the United States. Increasing prevalence of diabetes and diabetic atherosclerosis makes identification of molecular mechanisms by which diabetes promotes atherogenesis an important task. Targeting common pathways may ameliorate both diseases. This review focuses on well-known as well as newly discovered mechanisms which may represent promising therapeutic targets.

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U2 - 10.1016/j.ddmec.2007.12.005

DO - 10.1016/j.ddmec.2007.12.005

M3 - Review article

AN - SCOPUS:47049121292

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VL - 4

SP - 131

EP - 140

JO - Drug Discovery Today: Disease Mechanisms

JF - Drug Discovery Today: Disease Mechanisms

IS - 3

ER -

Mechanisms by which diabetes increases cardiovascular disease

Abstract

ASJC Scopus subject areas

UN SDGs

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