Mechanisms by which diabetes increases cardiovascular disease

Christian A. Gleissner, Elena Galkina, Jerry L. Nadler, Klaus Ley

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations

Abstract

Diabetes mellitus is one of the major risk factors for cardiovascular disease which is the leading cause of death in the United States. Increasing prevalence of diabetes and diabetic atherosclerosis makes identification of molecular mechanisms by which diabetes promotes atherogenesis an important task. Targeting common pathways may ameliorate both diseases. This review focuses on well-known as well as newly discovered mechanisms which may represent promising therapeutic targets.

Original languageEnglish (US)
Pages (from-to)131-140
Number of pages10
JournalDrug Discovery Today: Disease Mechanisms
Volume4
Issue number3
DOIs
StatePublished - Sep 2007
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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