Abstract
p53-mediated apoptosis of cells with DNA damage or oncogene overexpression is a major mechanism for its function as a tumor suppressor. Both transcriptionally dependent and transcriptionally independent activities of p53 can play a role in mediating cell death. It appears that p53 can induce apoptosis by multiple pathways in a manner which is regulated in a cell type and signal-specific fashion. Understanding the biochemical mechanisms of p53-dependent apoptosis holds a promise of manipulating these pathways in cancer therapy.
Original language | English (US) |
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Pages (from-to) | 83-98 |
Number of pages | 16 |
Journal | Critical Reviews in Oncogenesis |
Volume | 9 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 1998 |
Externally published | Yes |
Keywords
- Caspases
- Programmed cell death
- Tumor suppressors
- Tumor therapy
- Tumorigenesis
ASJC Scopus subject areas
- Cancer Research