Abstract
p53-mediated apoptosis of cells with DNA damage or oncogene overexpression is a major mechanism for its function as a tumor suppressor. Both transcriptionally dependent and transcriptionally independent activities of p53 can play a role in mediating cell death. It appears that p53 can induce apoptosis by multiple pathways in a manner which is regulated in a cell type and signal-specific fashion. Understanding the biochemical mechanisms of p53-dependent apoptosis holds a promise of manipulating these pathways in cancer therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 83-98 |
| Number of pages | 16 |
| Journal | Critical Reviews in Oncogenesis |
| Volume | 9 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1998 |
| Externally published | Yes |
Keywords
- Caspases
- Programmed cell death
- Tumor suppressors
- Tumor therapy
- Tumorigenesis
ASJC Scopus subject areas
- Cancer Research
