Medication management of antipsychotic treatment in schizophrenia—A narrative review

Matti Isohanni, Erika Jääskeläinen, Brian J. Miller, Anja Hulkko, Jari Tiihonen, Hans Jurgen Möller, Sirpa Hartikainen, Sanna Huhtaniska, Johannes Lieslehto

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Background/Objective: The risk-benefit ratio of antipsychotics in schizophrenia depends primarily on their effect on brain chemistry. An important factor influencing the efficacy of prescribed drugs is medication management, which can be defined as an ongoing process to manage and monitor the recommended use of antipsychotics to facilitate their cost-effective, adherent, and acceptable use. Materials: We reviewed narratively relevant literature that examined the medication management of antipsychotics in schizophrenia based on a search of PubMed, Scopus, Web of Science, PsycARTICLES, and Cochrane in May 2020. We also included controlled interventional studies with a follow-up period of at least 2 years. Result: Based on the previous literature, there is no unified approach for optimal medication management, but multiple useful strategies are presented for individual patients, prescribers, and organizations. Conclusions: Systematic medication management may improve the risk-benefit balance of antipsychotics by achieving the lowest effective dose, minimizing adverse effects, and improving adherence. There is a need for well-designed naturalistic studies and clinical trials to optimize management in schizophrenia.

Original languageEnglish (US)
Article numbere2765
JournalHuman Psychopharmacology
Issue number2
StatePublished - Mar 2021


  • antipsychotic medication
  • medication management
  • risk-benefit ratio
  • schizophrenia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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