TY - JOUR
T1 - Membership in genetic groups predicts Alzheimer disease
AU - Corder, Elizabeth H.
AU - Huang, Rong
AU - Cathcart, Heather M.
AU - Lanham, Irene S.
AU - Parker, Ginny R.
AU - Cheng, Danny
AU - Smith, Suzanne
AU - Poduslo, Shirley E.
PY - 2006/3
Y1 - 2006/3
N2 - The multiple polymorphisms contributing to Alzheimer disease (AD) have been difficult to identify. Three essentially sufficient risk sets were found using a fuzzy latent classification statistical model; that is, grade-of-membership analysis, and genotypes for APOE, APOCI, LDLr, cystatin C, and cathepsin D (180 cases, 120 controls). These were: (a) CST3-GA and CTSD:CT; (b) APOE44 and LDLr8:GG and LDLr13:TJ; and (c) APOE34 and LDLr13:TC. Consonance with one of the groups and high aggregate membership carried >800-fold elevated risk for AD. The absence of these combinations defined low risk. APOE3/- with heterozygous promoter and receptor genotypes predicted long life without dementia.
AB - The multiple polymorphisms contributing to Alzheimer disease (AD) have been difficult to identify. Three essentially sufficient risk sets were found using a fuzzy latent classification statistical model; that is, grade-of-membership analysis, and genotypes for APOE, APOCI, LDLr, cystatin C, and cathepsin D (180 cases, 120 controls). These were: (a) CST3-GA and CTSD:CT; (b) APOE44 and LDLr8:GG and LDLr13:TJ; and (c) APOE34 and LDLr13:TC. Consonance with one of the groups and high aggregate membership carried >800-fold elevated risk for AD. The absence of these combinations defined low risk. APOE3/- with heterozygous promoter and receptor genotypes predicted long life without dementia.
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U2 - 10.1089/rej.2006.9.89
DO - 10.1089/rej.2006.9.89
M3 - Article
C2 - 16608402
AN - SCOPUS:33646036987
SN - 1549-1684
VL - 9
SP - 89
EP - 93
JO - Rejuvenation Research
JF - Rejuvenation Research
IS - 1
ER -