Metal-Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Pooyan Makvandi, Chen yu Wang, Ehsan Nazarzadeh Zare, Assunta Borzacchiello, Li na Niu, Franklin R. Tay

Research output: Contribution to journalReview articlepeer-review

306 Scopus citations


Microbial colonization on material surfaces is ubiquitous. Biofilms derived from surface-colonized microbes pose serious problems to the society from both an economical perspective and a health concern. Incorporation of antimicrobial nanocompounds within or on the surface of materials, or by coatings, to prevent microbial adhesion or kill the microorganisms after their attachment to biofilms, represents an important strategy in an increasingly challenging field. Over the last decade, many studies have been devoted to preparing meta-based nanomaterials that possess antibacterial, antiviral, and antifungal activities to combat pathogen-related diseases. Herein, an overview on the state-of-the-art antimicrobial nanosized metal-based compounds is provided, including metal and metal oxide nanoparticles as well as transition metal nanosheets. The antimicrobial mechanism of these nanostructures and their biomedical applications such as catheters, implants, medical delivery systems, tissue engineering, and dentistry are discussed. Their properties as well as potential caveats such as cytotoxicity, diminishing efficacy, and induction of antimicrobial resistance of materials incorporating these nanostructures are reviewed to provide a backdrop for future research.

Original languageEnglish (US)
Article number1910021
JournalAdvanced Functional Materials
Issue number22
StatePublished - May 1 2020


  • antibacterial materials
  • antibacterial nanocomposites
  • antimicrobial metal nanoparticles
  • biomedicine
  • metal-based nanocompounds
  • transition metal nanosheets

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics


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