Microtubule disruption potentiates phenylephrine-induced vasoconstriction in rat mesenteric arterial bed

Romulo Leite; R. Clinton Webb

doi:10.1016/S0014-2999(98)00358-6

Microtubule disruption potentiates phenylephrine-induced vasoconstriction in rat mesenteric arterial bed

Romulo Leite, R. Clinton Webb

Physiology

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The pressor response induced by phenylephrine in the rat isolated mesenteric arterial bed was significantly increased following treatment with nocodazole, a drug that disassembles microtubules (10 μM, 90 min). This increase was even greater in the presence of nitric oxide (NO) synthase inhibition, and completely reversed by paclitaxel (20 μM), a stabilizer of microtubules. These results demonstrate that disassembly of microtubules enhances vasoconstriction to receptor activation, suggesting that the microtubules modulate the transduction of intracellular signals in endothelium and vascular smooth muscle cells.

Original language	English (US)
Pages (from-to)	R1-R3
Journal	European Journal of Pharmacology
Volume	351
Issue number	1
DOIs	https://doi.org/10.1016/S0014-2999(98)00358-6
State	Published - Jun 12 1998

Keywords

Blood vessel
Microtubule
Nocodazole

ASJC Scopus subject areas

Pharmacology

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10.1016/S0014-2999(98)00358-6

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title = "Microtubule disruption potentiates phenylephrine-induced vasoconstriction in rat mesenteric arterial bed",

abstract = "The pressor response induced by phenylephrine in the rat isolated mesenteric arterial bed was significantly increased following treatment with nocodazole, a drug that disassembles microtubules (10 μM, 90 min). This increase was even greater in the presence of nitric oxide (NO) synthase inhibition, and completely reversed by paclitaxel (20 μM), a stabilizer of microtubules. These results demonstrate that disassembly of microtubules enhances vasoconstriction to receptor activation, suggesting that the microtubules modulate the transduction of intracellular signals in endothelium and vascular smooth muscle cells.",

keywords = "Blood vessel, Microtubule, Nocodazole",

author = "Romulo Leite and Webb, {R. Clinton}",

note = "Funding Information: This study was supported by research grants and fellowships from the NIH (USA), Fubrigth Commission (USA) and CAPES (Brazil). Dr. Romulo Leite is a visiting researcher from the Department of Pharmacology, Federal University of Minas Gerais, Belo Horizonte, MG 31270-901, Brazil.",

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AU - Webb, R. Clinton

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PY - 1998/6/12

Y1 - 1998/6/12

N2 - The pressor response induced by phenylephrine in the rat isolated mesenteric arterial bed was significantly increased following treatment with nocodazole, a drug that disassembles microtubules (10 μM, 90 min). This increase was even greater in the presence of nitric oxide (NO) synthase inhibition, and completely reversed by paclitaxel (20 μM), a stabilizer of microtubules. These results demonstrate that disassembly of microtubules enhances vasoconstriction to receptor activation, suggesting that the microtubules modulate the transduction of intracellular signals in endothelium and vascular smooth muscle cells.

AB - The pressor response induced by phenylephrine in the rat isolated mesenteric arterial bed was significantly increased following treatment with nocodazole, a drug that disassembles microtubules (10 μM, 90 min). This increase was even greater in the presence of nitric oxide (NO) synthase inhibition, and completely reversed by paclitaxel (20 μM), a stabilizer of microtubules. These results demonstrate that disassembly of microtubules enhances vasoconstriction to receptor activation, suggesting that the microtubules modulate the transduction of intracellular signals in endothelium and vascular smooth muscle cells.

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KW - Microtubule

KW - Nocodazole

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Microtubule disruption potentiates phenylephrine-induced vasoconstriction in rat mesenteric arterial bed

Abstract

Keywords

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