Abstract
A simple, metal-free, cost-effective, and eco-friendly protocol for the preparation of trisubstituted 1,3,5 triazine from metformin using benzotriazole chemistry is reported. Short reaction time, large-scale synthesis, easy and quick isolation of the product, and excellent yield are the main advantages of this procedure. Furthermore, the use of benzotriazole chemistry results in a product free from metal traces. Our optimized reaction condition and methodology overcome the challenges of using a metal catalyst, such as a longer reaction time, lower yields, and expensive starting materials.
Original language | English (US) |
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Pages (from-to) | 516-524 |
Number of pages | 9 |
Journal | Reactions |
Volume | 3 |
Issue number | 4 |
DOIs | |
State | Published - Dec 2022 |
Keywords
- 1,3,5-triazine
- benzotriazole
- metformin
- microwave
- synthesis
ASJC Scopus subject areas
- Chemical Engineering (miscellaneous)
- Chemistry (miscellaneous)