TY - JOUR
T1 - Midterm benefits of preoperative statin therapy in patients undergoing isolated valve surgery
AU - Vaduganathan, Muthiah
AU - Stone, Neil J.
AU - Andrei, Adin Cristian
AU - Lee, Richard
AU - Kansal, Preeti
AU - Silverberg, Robert A.
AU - Bonow, Robert O.
AU - McCarthy, Patrick M.
N1 - Funding Information:
We would like to thank Brittany Lapin, Edwin C. McGee, S. Chris Malaisrie, Michael Yensel, Anna Huskin, and the Bluhm Cardiovascular Institute Clinical Trials Unit for their support and assistance with this project. There are no sources of financial support for this research. The authors had full control of the design of the study, methods used, outcome parameters and results, analysis of data, and production of the written report.
Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/6
Y1 - 2012/6
N2 - Background: Recent data have suggested that statins are associated with reduced early mortality and cardiovascular events after valvular heart surgery. The midterm effects of preoperative statin therapy in the setting of valvular heart surgery are presently unclear. Methods: All patients (n = 2,120) who underwent a valvular procedure between April 2004 and April 2010 were identified. Patients undergoing concomitant coronary artery bypass graft surgery were excluded. Two patient groups were studied: those who received preoperative statin therapy (n = 663; 31.3%) and those who did not (n = 1,457; 68.7%). Propensity score matching resulted in 381 matched pairs, thus addressing baseline risk imbalances. Thirty-day mortality, readmission rates, postoperative complications, and length of stay were analyzed. Late survival was ascertained by the Social Security Death Index. Results: In the matched group, 30-day mortality was 1.3% (5 of 381) for statin-treated patients versus 4.2% (16 of 381) for statin-untreated patients (p = 0.03). After a mean follow-up of 33 ± 23 months, statin therapy was associated with significantly reduced mortality (hazard ratio 0.63, 95% confidence interval: 0.43 to 0.93, p = 0.019), independent of known cardiac risk factors. Weighted log rank tests revealed that the mortality difference between the two cohorts occurred early after surgery (p = 0.015). Statin users were less likely to be readmitted to the intensive care unit (3.4% versus 8.1%, p = 0.01). There were no other significant differences between the two groups in terms of postoperative complications and length of stay. Conclusions: Preoperative statin administration is associated with early reductions in mortality among patients undergoing isolated valvular heart surgery, leading to improved late survival. Future prospective analyses are warranted to optimize statin therapy in this patient population.
AB - Background: Recent data have suggested that statins are associated with reduced early mortality and cardiovascular events after valvular heart surgery. The midterm effects of preoperative statin therapy in the setting of valvular heart surgery are presently unclear. Methods: All patients (n = 2,120) who underwent a valvular procedure between April 2004 and April 2010 were identified. Patients undergoing concomitant coronary artery bypass graft surgery were excluded. Two patient groups were studied: those who received preoperative statin therapy (n = 663; 31.3%) and those who did not (n = 1,457; 68.7%). Propensity score matching resulted in 381 matched pairs, thus addressing baseline risk imbalances. Thirty-day mortality, readmission rates, postoperative complications, and length of stay were analyzed. Late survival was ascertained by the Social Security Death Index. Results: In the matched group, 30-day mortality was 1.3% (5 of 381) for statin-treated patients versus 4.2% (16 of 381) for statin-untreated patients (p = 0.03). After a mean follow-up of 33 ± 23 months, statin therapy was associated with significantly reduced mortality (hazard ratio 0.63, 95% confidence interval: 0.43 to 0.93, p = 0.019), independent of known cardiac risk factors. Weighted log rank tests revealed that the mortality difference between the two cohorts occurred early after surgery (p = 0.015). Statin users were less likely to be readmitted to the intensive care unit (3.4% versus 8.1%, p = 0.01). There were no other significant differences between the two groups in terms of postoperative complications and length of stay. Conclusions: Preoperative statin administration is associated with early reductions in mortality among patients undergoing isolated valvular heart surgery, leading to improved late survival. Future prospective analyses are warranted to optimize statin therapy in this patient population.
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U2 - 10.1016/j.athoracsur.2012.02.091
DO - 10.1016/j.athoracsur.2012.02.091
M3 - Article
C2 - 22632489
AN - SCOPUS:84861635228
SN - 0003-4975
VL - 93
SP - 1881
EP - 1887
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
IS - 6
ER -