TY - JOUR
T1 - Modification of morphine antinociceptive response by blood glucose status
T2 - Possible involvement of cellular energetics
AU - Singh, Ishwar S.
AU - Chatterjee, Tapan K.
AU - Ghosh, Jagat J.
PY - 1983/6/17
Y1 - 1983/6/17
N2 - The antinociceptive response to morphine was enhanced in insulin-hypoglycemic animals whereas it was decreased in diabetic or in hypertonic glucose-pretreated hyperglycemic animals. 3-O-Methylglucose was, however, without effect on morphine analgesia whereas 2-deoxyglucose sensitized this effect. Furthermore, as malate and isocitrate attenuated the morphine analgesic response of insulin hypoglycemic animals and 2,4-dinitrophenol sensitized this response in diabetic animals, it is possible that the blood glucose level affects the morphine analgesic response by affecting cellular energetics.
AB - The antinociceptive response to morphine was enhanced in insulin-hypoglycemic animals whereas it was decreased in diabetic or in hypertonic glucose-pretreated hyperglycemic animals. 3-O-Methylglucose was, however, without effect on morphine analgesia whereas 2-deoxyglucose sensitized this effect. Furthermore, as malate and isocitrate attenuated the morphine analgesic response of insulin hypoglycemic animals and 2,4-dinitrophenol sensitized this response in diabetic animals, it is possible that the blood glucose level affects the morphine analgesic response by affecting cellular energetics.
KW - Blood glucose
KW - Cellular energetics
KW - Morphine analgesia
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U2 - 10.1016/0014-2999(83)90568-X
DO - 10.1016/0014-2999(83)90568-X
M3 - Article
C2 - 6350025
AN - SCOPUS:0020579748
SN - 0014-2999
VL - 90
SP - 437
EP - 439
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 4
ER -
