Multi-spectral imaging analysis of HSPB1 expression in head and neck squamous cell carcinoma

Julien A. Norton; Paul M. Weinberger; Mark A. Merkley; Sunny S. Khichi; Lana L. Jackson; William S. Dynan

doi:10.1002/lary.21635

Multi-spectral imaging analysis of HSPB1 expression in head and neck squamous cell carcinoma

Julien A. Norton, Paul M. Weinberger, Mark A. Merkley, Sunny S. Khichi, Lana L. Jackson, William S. Dynan

Otolaryngology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The objective of this study was to obtain more accurate quantitation of HSPB1 expression in HNSCC using a novel quantitative protein expression analysis system based on multispectral imaging. The study was a retrospective laboratory study of HNSCC patients treated at tertiary care academic medical center. Archival tissue samples from forty seven patients with HNSCC were subjected to immunohistochemistry using primary antibody to HSPB1. Seven of the patients had early stage cancers (TNM stage I/II) and forty patients had advanced stage cancers (TNM stage III/IV). HSPB1 expression was increased in advanced stage versus early stage cancers. Further investigation of HSPB1 as a potential biomarker for HNSCC is warranted.

Original language	English (US)
Pages (from-to)	S171
Journal	Laryngoscope
Volume	120
Issue number	SUPPL. 4
DOIs	https://doi.org/10.1002/lary.21635
State	Published - 2010

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/lary.21635

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abstract = "The objective of this study was to obtain more accurate quantitation of HSPB1 expression in HNSCC using a novel quantitative protein expression analysis system based on multispectral imaging. The study was a retrospective laboratory study of HNSCC patients treated at tertiary care academic medical center. Archival tissue samples from forty seven patients with HNSCC were subjected to immunohistochemistry using primary antibody to HSPB1. Seven of the patients had early stage cancers (TNM stage I/II) and forty patients had advanced stage cancers (TNM stage III/IV). HSPB1 expression was increased in advanced stage versus early stage cancers. Further investigation of HSPB1 as a potential biomarker for HNSCC is warranted.",

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AU - Norton, Julien A.

AU - Weinberger, Paul M.

AU - Merkley, Mark A.

AU - Khichi, Sunny S.

AU - Jackson, Lana L.

AU - Dynan, William S.

PY - 2010

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AB - The objective of this study was to obtain more accurate quantitation of HSPB1 expression in HNSCC using a novel quantitative protein expression analysis system based on multispectral imaging. The study was a retrospective laboratory study of HNSCC patients treated at tertiary care academic medical center. Archival tissue samples from forty seven patients with HNSCC were subjected to immunohistochemistry using primary antibody to HSPB1. Seven of the patients had early stage cancers (TNM stage I/II) and forty patients had advanced stage cancers (TNM stage III/IV). HSPB1 expression was increased in advanced stage versus early stage cancers. Further investigation of HSPB1 as a potential biomarker for HNSCC is warranted.

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Multi-spectral imaging analysis of HSPB1 expression in head and neck squamous cell carcinoma

Abstract

ASJC Scopus subject areas

UN SDGs

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