TY - JOUR
T1 - Multisystem Inflammatory Syndrome in an Adult with COVID-19 - A Trial of Anakinra
T2 - A Case Report
AU - Aggarwal, Abhimanyu
AU - Cohen, Ezra
AU - Figueira, Marisol
AU - Sabharwal, Vishakha
AU - Herlihy, Julie M.
AU - Bronwen, Carroll
AU - Barnett, Elizabeth D.
AU - Pelton, Stephen I.
AU - Camelo, Ingrid Y.
N1 - Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.
PY - 2021/11/1
Y1 - 2021/11/1
N2 - COVID-19 disease has been a pandemic caused by a β-coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A life-threatening multisystem inflammatory syndrome (MIS), secondary to SARS-CoV-2 virus infection, sharing common features with Kawasaki disease shock syndrome, staphylococcal/streptococcal shock syndrome, and macrophage activation syndrome in pediatric patients has been described. A total of 27 cases in adults (MIS-A) with a similar presentation have been reported so far. Here we describe the case of a 21-year-old man admitted with abdominal pain, diarrhea, tachycardia, and low blood pressure. He had elevated troponin, ferritin, and interleukin-2 receptor levels and had evidence of myocarditis. He tested positive for SARS-CoV-2 IgG antibody, and a diagnosis of MIS-A was made. Our case adds to the scant literature on this topic, and to our knowledge, it is the first case where anakinra was administered. He recovered well. MIS-A should be considered when young adults present with multiorgan dysfunction.
AB - COVID-19 disease has been a pandemic caused by a β-coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A life-threatening multisystem inflammatory syndrome (MIS), secondary to SARS-CoV-2 virus infection, sharing common features with Kawasaki disease shock syndrome, staphylococcal/streptococcal shock syndrome, and macrophage activation syndrome in pediatric patients has been described. A total of 27 cases in adults (MIS-A) with a similar presentation have been reported so far. Here we describe the case of a 21-year-old man admitted with abdominal pain, diarrhea, tachycardia, and low blood pressure. He had elevated troponin, ferritin, and interleukin-2 receptor levels and had evidence of myocarditis. He tested positive for SARS-CoV-2 IgG antibody, and a diagnosis of MIS-A was made. Our case adds to the scant literature on this topic, and to our knowledge, it is the first case where anakinra was administered. He recovered well. MIS-A should be considered when young adults present with multiorgan dysfunction.
KW - multisystem inflammatory syndrome
KW - myocarditis
KW - SARS-CoV-2
UR - http://www.scopus.com/inward/record.url?scp=85126580788&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85126580788&partnerID=8YFLogxK
U2 - 10.1097/IPC.0000000000001028
DO - 10.1097/IPC.0000000000001028
M3 - Article
AN - SCOPUS:85126580788
SN - 1056-9103
VL - 29
SP - E420-E423
JO - Infectious Diseases in Clinical Practice
JF - Infectious Diseases in Clinical Practice
IS - 6
ER -