Munc18-1 haploinsufficiency impairs learning and memory by reduced synaptic vesicular release in a model of Ohtahara syndrome

Keyphrases

• Behavioral Tests 10%
• Burst Suppression 10%
• Cellular Effects 10%
• Cognitive Impairment 20%
• FM Dye 10%
• Haploinsufficiency 100%
• Heterozygous Knockout 10%
• Hippocampal CA1 Region 10%
• Hippocampal Neurons 10%
• Impaired Cognition 20%
• Infantile Epileptic Encephalopathy 10%
• Knock-in Mouse Model 10%
• Long-term Potentiation 10%
• Molecular Mechanism 10%
• Mouse Model 10%
• Munc18-1 100%
• Neurotransmitter Release 10%
• Ohtahara Syndrome 100%
• Physiological Function 10%
• Releasable 10%
• Sec Proteins 10%
• Seizure 10%
• Spatial Learning 10%
• Spatial Memory 10%
• STXBP1 10%
• Synaptic 100%
• Synaptic Plasticity 10%
• Synaptic Vesicle Release 10%
• Vesicle Pools 10%
• Vesicular Release 100%

Neuroscience

• Behavior (Neuroscience) 16%
• Cognitive Disorders 33%
• Encephalopathy 16%
• Haploinsufficiency 100%
• Long-Term Potentiation 16%
• Munc18 Protein 16%
• Neurotransmitter Release 16%
• Synaptic Plasticity 16%
• Synaptic Vesicle Release 16%