Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for in Vivo Cancer Treatment

Hongmin Chen; Geoffrey D. Wang; Yen Jun Chuang; Zipeng Zhen; Xiaoyuan Chen; Paul Williams Biddinger; Zhonglin Hao; Feng Liu; Baozhong Shen; Zhengwei Pan; Jin Xie

doi:10.1021/nl504044p

Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for in Vivo Cancer Treatment

Hongmin Chen, Geoffrey D. Wang, Yen Jun Chuang, Zipeng Zhen, Xiaoyuan Chen, Paul Williams Biddinger, Zhonglin Hao, Feng Liu, Baozhong Shen, Zhengwei Pan, Jin Xie

Research output: Contribution to journal › Article › peer-review

308 Scopus citations

Abstract

Photodynamic therapy is a promising treatment method, but its applications are limited by the shallow penetration of visible light. Here, we report a novel X-ray inducible photodynamic therapy (X-PDT) approach that allows PDT to be regulated by X-rays. Upon X-ray irradiation, the integrated nanosystem, comprised of a core of a nanoscintillator and a mesoporous silica coating loaded with photosensitizers, converts X-ray photons to visible photons to activate the photosensitizers and cause efficient tumor shrinkage.

Original language	English (US)
Pages (from-to)	2249-2256
Number of pages	8
Journal	Nano Letters
Volume	15
Issue number	4
DOIs	https://doi.org/10.1021/nl504044p
State	Published - Apr 8 2015

Keywords

X-PDT
cancer treatment
nanomedicine
nanoscintillator
radioluminescence nanophosphors
singlet oxygen

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/nl504044p

Cite this

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title = "Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for in Vivo Cancer Treatment",

abstract = "Photodynamic therapy is a promising treatment method, but its applications are limited by the shallow penetration of visible light. Here, we report a novel X-ray inducible photodynamic therapy (X-PDT) approach that allows PDT to be regulated by X-rays. Upon X-ray irradiation, the integrated nanosystem, comprised of a core of a nanoscintillator and a mesoporous silica coating loaded with photosensitizers, converts X-ray photons to visible photons to activate the photosensitizers and cause efficient tumor shrinkage.",

keywords = "X-PDT, cancer treatment, nanomedicine, nanoscintillator, radioluminescence nanophosphors, singlet oxygen",

author = "Hongmin Chen and Wang, {Geoffrey D.} and Chuang, {Yen Jun} and Zipeng Zhen and Xiaoyuan Chen and Biddinger, {Paul Williams} and Zhonglin Hao and Feng Liu and Baozhong Shen and Zhengwei Pan and Jin Xie",

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doi = "10.1021/nl504044p",

language = "English (US)",

volume = "15",

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journal = "Nano Letters",

issn = "1530-6984",

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T1 - Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for in Vivo Cancer Treatment

AU - Chen, Hongmin

AU - Wang, Geoffrey D.

AU - Chuang, Yen Jun

AU - Zhen, Zipeng

AU - Chen, Xiaoyuan

AU - Biddinger, Paul Williams

AU - Hao, Zhonglin

AU - Liu, Feng

AU - Shen, Baozhong

AU - Pan, Zhengwei

AU - Xie, Jin

PY - 2015/4/8

Y1 - 2015/4/8

N2 - Photodynamic therapy is a promising treatment method, but its applications are limited by the shallow penetration of visible light. Here, we report a novel X-ray inducible photodynamic therapy (X-PDT) approach that allows PDT to be regulated by X-rays. Upon X-ray irradiation, the integrated nanosystem, comprised of a core of a nanoscintillator and a mesoporous silica coating loaded with photosensitizers, converts X-ray photons to visible photons to activate the photosensitizers and cause efficient tumor shrinkage.

AB - Photodynamic therapy is a promising treatment method, but its applications are limited by the shallow penetration of visible light. Here, we report a novel X-ray inducible photodynamic therapy (X-PDT) approach that allows PDT to be regulated by X-rays. Upon X-ray irradiation, the integrated nanosystem, comprised of a core of a nanoscintillator and a mesoporous silica coating loaded with photosensitizers, converts X-ray photons to visible photons to activate the photosensitizers and cause efficient tumor shrinkage.

KW - X-PDT

KW - cancer treatment

KW - nanomedicine

KW - nanoscintillator

KW - radioluminescence nanophosphors

KW - singlet oxygen

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Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for in Vivo Cancer Treatment

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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