TY - JOUR
T1 - Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases
AU - Mei, Lin
AU - Nave, Klaus Armin
N1 - Funding Information:
We wish to thank C. Lai, M. Schwab, H. Ehrenreich, F. Tang, and D. Yin for frequent discussion; A. Buonanno, H. Kim, A. Law, B. Li, O. Marin, P. Penzes, D. Talmage, and C. Weickert for comments on earlier versions or parts of them; J. Bean, Y. Chen, D. Figueiredo, T. Lin, J. Meixiong, L. Prusinski, and A. Sathyamurthy for suggestions; H. Wu and F. Tang for assistance with figures; and anonymous reviewers for constructive comments. L.M. was a member of scientific advisory board of Mind-NRG, Switzerland; K.A.N. is a member of the scientific advisory board of Lundbeck A/S. Work of the authors’ laboratory was supported by grants from NIH, NARSAD, and VA Merit Award to L.M. and by the Cluster of Excellence and DFG Research Center “Nanoscale Microscopy and Molecular Physiology of the Brain” and an ERC Advanced Grant to K.A.N.
PY - 2014/7/2
Y1 - 2014/7/2
N2 - Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility genes for diseases such as schizophrenia (SZ) and bipolar disorder. Recent studies have revealed complex Nrg/Erbb signaling networks that regulate the assembly of neural circuitry, myelination, neurotransmission, and synaptic plasticity. Evidence indicates there is an optimal level of NRG/ERBB signaling in the brain and deviation from it impairs brain functions. NRGs/ERBBs and downstream signaling pathways may provide therapeutic targets for specific neuropsychiatric symptoms. Neuregulins (NRGs) comprise a family of growth factors that activate ERBB receptor kinases. Mei and Nave review the role of Nrg-Erbb signaling in neural development, myelination, and synaptic plasticity and the possible contribution of abnormal NRG1 signaling to brain disorders.
AB - Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility genes for diseases such as schizophrenia (SZ) and bipolar disorder. Recent studies have revealed complex Nrg/Erbb signaling networks that regulate the assembly of neural circuitry, myelination, neurotransmission, and synaptic plasticity. Evidence indicates there is an optimal level of NRG/ERBB signaling in the brain and deviation from it impairs brain functions. NRGs/ERBBs and downstream signaling pathways may provide therapeutic targets for specific neuropsychiatric symptoms. Neuregulins (NRGs) comprise a family of growth factors that activate ERBB receptor kinases. Mei and Nave review the role of Nrg-Erbb signaling in neural development, myelination, and synaptic plasticity and the possible contribution of abnormal NRG1 signaling to brain disorders.
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U2 - 10.1016/j.neuron.2014.06.007
DO - 10.1016/j.neuron.2014.06.007
M3 - Review article
C2 - 24991953
AN - SCOPUS:84903650231
SN - 0896-6273
VL - 83
SP - 27
EP - 49
JO - Neuron
JF - Neuron
IS - 1
ER -