Neurologic toxicity associated with hepatic artery infusion HAI of FUdR

H. Grant Taylor; Charles R. Wolf; Charles G. Maitland

doi:10.1007/BF00256703

Neurologic toxicity associated with hepatic artery infusion HAI of FUdR

H. Grant Taylor, Charles R. Wolf, Charles G. Maitland

Research output: Contribution to journal › Article › peer-review

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Abstract

A 66-year-old man with hepatic metastases from gastric adenocarcinoma was treated on two occasions with 5-fluoro-2-deoxyuridine (FUdR) via hepatic artery infusion (HAI). The patient developed neurologic signs and symptoms including disorientation, oculomotor defects, ataxia and multifocal myoclonus during both attempts at HAI. Systemic drug toxicity is unusual when FUdR is given via HAI, and neurologic toxicity has not previously been reported. We postulate individual hypersensitivity to FUdR or selective concentration of FUdR in brainstem structures to explain the toxicity in this case.

Original language	English (US)
Pages (from-to)	292-293
Number of pages	2
Journal	Cancer Chemotherapy and Pharmacology
Volume	17
Issue number	3
DOIs	https://doi.org/10.1007/BF00256703
State	Published - Jul 1 1986
Externally published	Yes

ASJC Scopus subject areas

Oncology
Toxicology
Pharmacology
Cancer Research
Pharmacology (medical)

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10.1007/BF00256703

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title = "Neurologic toxicity associated with hepatic artery infusion HAI of FUdR",

abstract = "A 66-year-old man with hepatic metastases from gastric adenocarcinoma was treated on two occasions with 5-fluoro-2-deoxyuridine (FUdR) via hepatic artery infusion (HAI). The patient developed neurologic signs and symptoms including disorientation, oculomotor defects, ataxia and multifocal myoclonus during both attempts at HAI. Systemic drug toxicity is unusual when FUdR is given via HAI, and neurologic toxicity has not previously been reported. We postulate individual hypersensitivity to FUdR or selective concentration of FUdR in brainstem structures to explain the toxicity in this case.",

author = "{Grant Taylor}, H. and Wolf, {Charles R.} and Maitland, {Charles G.}",

year = "1986",

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T1 - Neurologic toxicity associated with hepatic artery infusion HAI of FUdR

AU - Grant Taylor, H.

AU - Wolf, Charles R.

AU - Maitland, Charles G.

PY - 1986/7/1

Y1 - 1986/7/1

N2 - A 66-year-old man with hepatic metastases from gastric adenocarcinoma was treated on two occasions with 5-fluoro-2-deoxyuridine (FUdR) via hepatic artery infusion (HAI). The patient developed neurologic signs and symptoms including disorientation, oculomotor defects, ataxia and multifocal myoclonus during both attempts at HAI. Systemic drug toxicity is unusual when FUdR is given via HAI, and neurologic toxicity has not previously been reported. We postulate individual hypersensitivity to FUdR or selective concentration of FUdR in brainstem structures to explain the toxicity in this case.

AB - A 66-year-old man with hepatic metastases from gastric adenocarcinoma was treated on two occasions with 5-fluoro-2-deoxyuridine (FUdR) via hepatic artery infusion (HAI). The patient developed neurologic signs and symptoms including disorientation, oculomotor defects, ataxia and multifocal myoclonus during both attempts at HAI. Systemic drug toxicity is unusual when FUdR is given via HAI, and neurologic toxicity has not previously been reported. We postulate individual hypersensitivity to FUdR or selective concentration of FUdR in brainstem structures to explain the toxicity in this case.

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JO - Cancer Chemotherapy and Pharmacology

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Neurologic toxicity associated with hepatic artery infusion HAI of FUdR

Abstract

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