TY - JOUR
T1 - Neuron-targeted exosome therapy
T2 - A novel approach for treating cardiogenic dementia via RyR2 inhibition
AU - Saxena, Richa
AU - Tang, Yaoliang
N1 - Publisher Copyright:
© 2024 Elsevier Ltd
PY - 2024/2
Y1 - 2024/2
N2 - Cardiogenic dementia (CD), recognized since the late 1970s, manifests as altered consciousness and cognition due to heart conditions. Its elusive molecular mechanisms present diagnostic and management challenges. Emerging research implicates ryanodine receptor type 2 (RyR2) mediated intracellular Ca2 + leaks in myocardial infarction (MI)-linked cognitive impairment. We hypothesize that intravenous delivery of neuron-targeted exosomes loaded with RyR2-targeting siRNA (si-RyR2) to cerebral regions could rectify Ca2 + imbalance, curbing neurotoxic protein generation tied to CD. To investigate, si-RyR2 exosomes will be administered to MI-induced mice, with hippocampal samples analyzed for Ca2 + levels, β-amyloid, and p-tau. Results hold promise for advancing CD treatment insights.
AB - Cardiogenic dementia (CD), recognized since the late 1970s, manifests as altered consciousness and cognition due to heart conditions. Its elusive molecular mechanisms present diagnostic and management challenges. Emerging research implicates ryanodine receptor type 2 (RyR2) mediated intracellular Ca2 + leaks in myocardial infarction (MI)-linked cognitive impairment. We hypothesize that intravenous delivery of neuron-targeted exosomes loaded with RyR2-targeting siRNA (si-RyR2) to cerebral regions could rectify Ca2 + imbalance, curbing neurotoxic protein generation tied to CD. To investigate, si-RyR2 exosomes will be administered to MI-induced mice, with hippocampal samples analyzed for Ca2 + levels, β-amyloid, and p-tau. Results hold promise for advancing CD treatment insights.
KW - Cardiogenic dementia
KW - Exosome
KW - Myocardial infarction
KW - Neuron-targeted peptides
KW - Ryanodine receptor 2 (RyR2)
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U2 - 10.1016/j.mehy.2024.111266
DO - 10.1016/j.mehy.2024.111266
M3 - Article
AN - SCOPUS:85182365709
SN - 0306-9877
VL - 183
JO - Medical Hypotheses
JF - Medical Hypotheses
M1 - 111266
ER -