Neuronal growth-inhibitory factor (metallothionein-3): Structure-function relationships

Zhi Chun Ding, Feng Yun Ni, Zhong Xian Huang

Research output: Contribution to journalShort surveypeer-review

31 Scopus citations


Neuronal growth-inhibitory factor (GIF), also named metallothionein-3, inhibits the outgrowth of neuronal cells. Recent studies on the structure of human GIF, carried out using NMR and molecular dynamics simulation techniques, have been summarized. By studying a series of protein-engineered mutants of GIF, we showed that the bioactivity of GIF is modulated by multiple factors, including the unique TCPCP motif-induced characteristic conformation, the solvent accessibility and dynamics of the metal-thiolate cluster, and the domain-domain interactions.

Original languageEnglish (US)
Pages (from-to)2912-2920
Number of pages9
JournalFEBS Journal
Issue number14
StatePublished - Jul 2010
Externally publishedYes


  • metallothionein (MT)
  • mutation
  • neuronal growth-inhibitory factor (GIF)
  • structure-function relationship

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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