TY - JOUR
T1 - Neutrophils in cancer
T2 - heterogeneous and multifaceted
AU - Hedrick, Catherine C.
AU - Malanchi, Ilaria
N1 - Funding Information:
The authors thank D. Araujo (La Jolla Institute for Immunology (LJI)) for helpful edits, E. Nolan (The Francis Crick Institute) for critically reading the manuscript and H. Q. Dinh (University of Wisconsin-Madison) and M. A. Meyer (LJI) for helpful discussion of neutrophil developmental trajectories. This work was supported in part by the US National Institutes for Health (P01HL152958, P01HL136275 and U01CA224766 to C.C.H.), and by the Francis Crick Institute, which receives its core funding from Cancer Research UK (FC001112), the UK Medical Research Council (FC001112) and the Wellcome Trust (FC001112), and by a European Research Council grant (CoG-H2020-725492 to I.M).
Publisher Copyright:
© 2021, Springer Nature Limited.
PY - 2022/3
Y1 - 2022/3
N2 - Neutrophils are the most abundant myeloid cells in human blood and are emerging as important regulators of cancer. However, their functional importance has often been overlooked on the basis that they are short-lived, terminally differentiated and non-proliferative. Recent studies of their prominent roles in cancer have led to a paradigm shift in our appreciation of neutrophil functional diversity. This Review describes how neutrophil diversification, which in some contexts can lead to opposing functions, is generated within the tumour microenvironment as well as systemically. We compare neutrophil heterogeneity in cancer and in other pathophysiological contexts to provide an updated overview of our current knowledge of the functions of neutrophils in cancer.
AB - Neutrophils are the most abundant myeloid cells in human blood and are emerging as important regulators of cancer. However, their functional importance has often been overlooked on the basis that they are short-lived, terminally differentiated and non-proliferative. Recent studies of their prominent roles in cancer have led to a paradigm shift in our appreciation of neutrophil functional diversity. This Review describes how neutrophil diversification, which in some contexts can lead to opposing functions, is generated within the tumour microenvironment as well as systemically. We compare neutrophil heterogeneity in cancer and in other pathophysiological contexts to provide an updated overview of our current knowledge of the functions of neutrophils in cancer.
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U2 - 10.1038/s41577-021-00571-6
DO - 10.1038/s41577-021-00571-6
M3 - Review article
C2 - 34230649
AN - SCOPUS:85109830221
SN - 1474-1733
VL - 22
SP - 173
EP - 187
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 3
ER -
